Abstract
This study was undertaken to investigate the effects of fluoride on growth and thyroid function in young pigs. Three groups of eight crossbred barrows were exposed to 100, 250, and 400 mg F– /kg (from NaF) in their diets for 50 days. Compared to a control group of eight pigs, the average daily gain in weight was significantly reduced, and serum thyroxine (T4) and free thyroxine (FT4) levels also decreased significantly. On the other hand, the level of serum thyroid-stimulating hormone (TSH) was significantly increased, but no significant differences were observed in serum triiodothyronine (T3) and free triiodothyronine (FT3). The activity of Na/K-ATPase in the thyroid was significantly inhibited as well as thyroid peroxidase (TPO). The results suggest that excessive fluoride in the diet can cause growth depression and hypothyroxinemia in pigs. Accompanying thyroid lesions were attributed to fluoride acting as a TSH analogue in concert with elevated TSH level.
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y-Aminobutyric acid ameliorates fluoride-induced hypothyroidism in male kunming mice
AIM: This study evaluated the protective effects of y-aminobutyric acid (GABA), a non-protein amino acid and anti-oxidant, against fluoride-induced hypothyroidism in mice. MAIN METHODS: light microscope sample preparation technique and TEM sample preparation technique were used to assay thyroid microstructure and ultrastructure; enzyme immunoassay method was used to assay hormone and
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[Effects of fluoride on the thyroid morphology and thyroid peroxidase and serum thyroid hormones].
Objective To observe the effects of fluoride on thyroid morphology,thyroid peroxidase and serum thyroid hormones. Methods One - month ablactating SD rats were randomly divided into three groups:the control group, low-fluoride group, middle-fluoride group, high-fluoride group, fed with water containing different fluoride concentration by adding NaF respectively. Rats were sacrificed after
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[Chronic effects of fluorides on the pituitary-thyroid system in industrial workers].
Radioimmunologic study of thyrotropin and thyroid hormones in the blood of those engaged in fluorine production showed moderate functional changes of the hypophysis-thyroid gland system, not accompanied by clinical manifestations of hypo- or hyperthyreosis and caused by disorders of the regulatory chain and fluorine impact on thyroid hormones' metabolism at
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Is water fluoridation a hidden cause of obesity? Histological study on thyroid follicular cells of albino rats
Introduction: Fluoride in drinking water is known to exert both beneficial and detrimental effects on health. When consumed in excess, it is known to cause adverse effects including dental fluorosis, hip fracture, bone cancer, lower intelligence, and kidney toxicity plus goiter. Aim: This study was carried out to determine the histological
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Fluoride caused thyroid endocrine disruption in male zebrafish (Danio rerio)
Highlights Fluoride inhibited the growth of male zebrafish. Fluoride injured the histological structure of thyroid in male zebrafish. Fluoride changed T3 and T4 levels, and genes transcriptions involved in HPT axis. Excessive fluoride in natural water ecosystem has the potential to detrimentally affect thyroid endocrine system, but little is known
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Fluoride's Impact on Thyroid Hormones
Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as
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Is fluoride-induced hyperthyroidism a cause of psychosis among East African immigrants to Scandinavia?
When people with a compensated fluoride-induced hypothyroidism move to a low-fluoride area, the fluoride-induced inhibition of the production of thyroid hormones ceases. In Scandinavia, the dietary intake of iodine is usually quite high due to iodized table salt and easy access to marine fish. Under these conditions, the elevated capacity for production of thyroid hormones may result in hyperthyroidism.
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The Relationship Between Fluoride Exposure & Goitre in South Africa
As a general rule simple goitre, irrespective of the cause, can be very, or fairly, satisfactorily combated by an adequate increase in man's daily iodine intake, except when the enlargement of the gland is due to the ingestion of excessive amounts of fluorine. The only correct solution to fluorine-induced endemic goitre is the removal of this element from the drinking water.
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Fluoride & Goiter
Goitre (aka goiter) is an enlargement of the thyroid gland that in some cases can produce visible swelling in the neck. The main cause of goitre is iodine deficiency. Goitre can also be caused by other things, including hypothyroidism and substances that cause goitre (goitrogens). Since as far back as the
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Fluorine in the Aetiology of Endemic Goitre
The distribution of endemic goitre in the Punjab and in England is related to the geological distribution of fluorine and to the distribution of human dental fluorosis (mottled enamel). Inquiry showed the presence of dental fluorosis among school-children in two areas of Somerset where two previous observers had recorded a high incidence of goitre, and the absence of dental fluorosis in an adjoining area selected as control where endemic goitre was absent.
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