Abstract
Objective: To understand the relationship between fluorosis and adult osteoarthritis through the investigation of fluorosis-afflicted villages.
Methods: X-ray radiography of right hands was performed on 227 adults over the age of 40 from fluorosis-afflicted villages, and adult osteoarthritis was diagnosed using accumulated scores based on the obtained results.
Results: The identification rate of osteoarthritis in fluorosis-afflicted regions was 59.03%, and the mean accumulated score was 3.85, both significantly higher than those for the control population (identification rate was 23.6%, mean accumulated score was 0.72); patients with osteoarthritis caused by fluorosis accounted for a considerable portion of the osteoarthritis population.
Conclusions: Fluorosis may lead to osteoarthritis, and also acts as a confounding factor of adult Kashin-Beck disease (KBD) in a portion of patients.
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Crippling fluorosis related to fluoride intake (case report).
In a 55 year-old woman with long-standing arthritis, but no obvious signs of fluorosis, X-rays exhibited degeneration of discs and calcification in disc spaces. Her daily fluoride intake, mainly from tea, exceeded 9 mg; her daily urinary excretion was 3 mg. When she discontinued consuming tea, her fluoride intake fell
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Dorsal spondylolisthesis secondary to chronic fluoride intoxication: one case report
Fluorosis is a disease caused by an excess of fluoride in the water, it is endemic in many parts of India,Afghanistan; Irak, Iran and North Africa. Fluoride is retained in the bones and induces hardening of all the bones, including the spine, hypertrophy of the joints and bones is seen,
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Endemic fluorosis in Turkish patients: relationship with knee osteoarthritis
Fluoride excess primarily effects dental and skeletal tissues. leading to a condition known as endemic fluorosis. The radiological and clinical features of endemic fluorosis vary in different parts of the world. The aim of this study was to investigate the clinical and radiological features of endemic fluorosis in Turkish patients. Physical examination and radiological investigations were performed
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Comparison of rheumatoid (ankylosing) spondylitis and crippling fluorosis
(1) Fluoride concentrations were determined for autopsy samples of rib, sacrum, ilium, vertebra, adhering soft tissue, and rib marrow from a patient suffering from rheumatoid (ankylosing) spondylitis of 10 years’ duration. The fluoride concentrations were not increased above normal levels. In this case, the increased bone density seen in this
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X-ray changes in the forearm and crus of residents of areas in Jilin Province with varying drinking water fluoride concentrations
GOAL: To understand the characteristics of forearm and crus X-rays of residents from areas with varying concentrations of fluoride in their drinking water, providing evidence for diagnosis of osteofluorosis. METHOD: Using quantificational epidemiological methods, a total of 15 villages from Qianan and Nonan Counties of Jilin Province were selected as the
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Fluoride & Osteoarthritis
While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.
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Skeletal Fluorosis: The Misdiagnosis Problem
It is a virtual certainty that there are individuals in the general population unknowingly suffering from some form of skeletal fluorosis as a result of a doctor's failure to consider fluoride as a cause of their symptoms. Proof that this is the case can be found in the following case reports of skeletal fluorosis written by doctors in the U.S. and other western countries. As can be seen, a consistent feature of these reports is that fluorosis patients--even those with crippling skeletal fluorosis--are misdiagnosed for years by multiple teams of doctors who routinely fail to consider fluoride as a possible cause of their disease.
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"Pre-Skeletal" Fluorosis
As demonstrated by the studies below, skeletal fluorosis may produce adverse symptoms, including arthritic pains, clinical osteoarthritis, gastrointestinal disturbances, and bone fragility, before the classic bone change of fluorosis (i.e., osteosclerosis in the spine and pelvis) is detectable by x-ray. Relying on x-rays, therefore, to diagnosis skeletal fluorosis will invariably fail to protect those individuals who are suffering from the pre-skeletal phase of the disease. Moreover, some individuals with clinical skeletal fluorosis will not develop an increase in bone density, let alone osteosclerosis, of the spine. Thus, relying on unusual increases in spinal bone density will under-detect the rate of skeletal fluoride poisoning in a population.
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