Abstract
The study contains the results of fluoride testing done on 31 fetal specimens. It demonstrates that fluoride can pass through the placenta into the fetus, that bone tissues shows the highest levels of fluoride while brain tissue shows the lowest, and that overall level of fluoride increases with the fluoride burden of the mother and the age of the fetus.
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Bioavailability of fluoride in drinking water: a human experimental study
It has been suggested that systemic fluoride absorption from drinking water may be influenced by the type of fluoride compound in the water and by water hardness. Using a human double-blind cross-over trial, we conducted this study to measure c(max), T(max), and Area Under the Curve (AUC) for plasma F
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Fluoride pharmacokinetics in infancy
Fluoride pharmacokinetic data are presented for infants given a fluoride supplement. Seventeen infants participated in a total of 20 studies. On one day, 0.013 mmol (0.25 mg) fluoride was given as a supplement (fluoride supplement study), and on another day a placebo was given (control study). Samples of plasma and
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Water fluoridation and congenital malformations: no association
Data based on a total number of 1,387,027 births were used to compare the incidence of selected congenital malformations in fluoridated areas and that in areas where the water supply is deficient in fluoride. The incidence of selected congenital malformations in areas with fluoride supplementation of public water supplies was compared
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Influence of genetic background on fluoride metabolism in mice
A/J and 129P3/J mouse strains have different susceptibilities to dental fluorosis, due to their genetic backgrounds. This study tested whether these differences are due to variations in water intake and/or F metabolism. A/J (susceptible to dental fluorosis) and 129P3/J mice (resistant) received drinking water containing 0, 10, or 50 ppm
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The effect of fluorine on the developing human brain.
Fifteen fetuses from an endemic fluorosis area that were aborted therapeutically at the 5th–8th month of gestation were compared with 16 aborted fetuses from a non-endemic area. Stereological study of the brains showed that the numerical density of the neuron volume and the undifferentiated neuroblasts as well as the nucleus-cytoplasm ratio of the neurons were
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