Abstract
The study contains the results of fluoride testing done on 31 fetal specimens. It demonstrates that fluoride can pass through the placenta into the fetus, that bone tissues shows the highest levels of fluoride while brain tissue shows the lowest, and that overall level of fluoride increases with the fluoride burden of the mother and the age of the fetus.
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Intake and metabolism of fluoride
The purpose of this paper is to discuss the major factors that determine the body burden of inorganic fluoride. Fluoride intake 25 or more years ago was determined mainly by measurement of the concentration of the ion in the drinking water supply. This is not necessarily true today because of
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Urticaria due to fluorides
Six cases of urticaria are reported in which trace quantities of fluoride proved to have played a major etiological role. The causative relationship was established by blindfold tests, by the history and by the concomittant symptomatology. Following an oral test dose of fluoride given to five of the six cases
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Fluoride down-regulates the expression of matrix metalloproteinase-20 in human fetal tooth ameloblast-lineage cells in vitro.
Fluoride is associated with a decrease in the incidence of dental caries, but excessive fluoride intake during tooth enamel formation can result in enamel fluorosis. Fluorosed enamel has increased porosity, which has been related to a delay in the removal of amelogenin proteins as the enamel matures. This delay in
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Effect of high-dose fluoride on antioxidant enzyme activities of amniotic fluid in rats.
OBJECTIVE: To investigate the effect of high-dose fluoride on antioxidant enzyme activities of amniotic fluid and fluoride of serum in rats. METHODS: The experimental study was conducted from January 8, 2008, to December 14, 2010, at the Suleyman Demirel University Experimental Animals Laboratory and the Medical Biochemistry Department Research Laboratory, Isparta,
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A comparative study of fluoride pharmacokinetics in five species
This study was designed to quantitate and compare the major features of the short-term pharmacokinetics of fluoride--i.e., the plasma (Cp), renal (Cr), and extra-renal (Cer) clearances--in young adult dogs, cats, rabbits, rats, and hamsters. Plasma and urine samples were collected for seven h after the iv administration of fluoride (0.5
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