The present research report has looked into the correlation between male infertility and the fluoride level in water, the occurrence of dental and skeletal fluorosis, [the volume and quality of] semen and the amount of fluoride contained therein. Results have shown that fluoride might be a leading cause of male infertility in regions with endemic fluorosis.
In silico prediction of microRNAs on fluoride induced sperm toxicity in mice
Fluorosis is an endemic global problem causing male reproductive impairment. F mediates male reproductive toxicity in mice down-regulating 63 genes involved in diverse biological processes - apoptosis, cell cycle, cell signaling, chemotaxis, electron transport, glycolysis, oxidative stress, sperm capacitation and spermatogenesis. We predicted the miRNAs down-regulating these 63 genes using
[Fluorosis of coal burning affects the male reproductive system].
Fluorosis of coal burning is a new type of endemic fluorosis in China, which affects the male reproductive system. Furthermore, the content of fluoride in the semen, sperm mortality, sperm concentration and the incidence of infertility are higher in severe fluorosis areas than in mild- and non-fluorosis areas, so are
Effects of fluoride and aluminum on expressions of StAR and P450scc of related steroidogenesis in guinea pigs' testis
Highlights F and Al changed histological structure of testes, reduced sperm quality. F and Al reduced StAR and P450scc expressions and level of serum testosterone. F toxicity is stronger than Al and Al weakened the toxicity of F. Al had antagonism effects on F. A lot of studies have shown
Ameliorative effects of reduced food-borne fluoride on reproduction in silver foxes
Reduction of ingested fluoride in a skulk of silver foxes resulted in the reduction of fluoride burden, decreased neonatal mortality and increased kit production during a two breeding and whelping season period.
Multigenerational evaluation of sodium fluoride in rats
Since the mid 1940s, fluoride has been added to tap water in American communities in an effort to reduce the incidence of dental caries in the population. When the levels of fluoride in drinking water were tested and set, water was the only measurable source of fluoride for most communities.
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