The present research report has looked into the correlation between male infertility and the fluoride level in water, the occurrence of dental and skeletal fluorosis, [the volume and quality of] semen and the amount of fluoride contained therein. Results have shown that fluoride might be a leading cause of male infertility in regions with endemic fluorosis.
Multigenerational evaluation of sodium fluoride in rats
Since the mid 1940s, fluoride has been added to tap water in American communities in an effort to reduce the incidence of dental caries in the population. When the levels of fluoride in drinking water were tested and set, water was the only measurable source of fluoride for most communities.
Reversal of fluoride-induced alteration in cauda epididymal spermatozoa and fertility impairment in male mice
The effects of sodium fluoride (NaF) ingestion (10 mg NaF/kg body weight) and the possible therapeutic effects of ascorbic acid (AA, 15 mg/animal/day) and/or calcium phosphate (Ca, 25 mg/animal/day) on the reproductive functions and fertility of male mice were investigated. NaF-ingestion brought about a significant decline in sperm acrosomal acrosin
Amelioration of fluoride toxicity in some accessory reproductive glands and spermatozoa of rat
Sodium fluoride (NaF) at a dose of 10 mg/kg body weight was administered orally to male rats (Rettus norvegicus) daily for 30 and 50 days to evaluate the effect of the physiology of some sex accessory glands and sperm functions. The effects of withdrawal upon cessation of NaF ingestion, and
Natrium fluoride influences methylation modifications and induces apoptosis in mouse early embryos
Fluoride is considered a major pollutant of ground water and can cause cytotoxicity in a concentration-dependent manner. This study epigenetically examined the effect of fluoride on early embryos of Kunming mice administered with 0, 20, 60, and 120 mg/L sodium fluoride (NaF) for 30 days. The results showed that NaF
Fluoride impairs oocyte maturation and subsequent embryonic development in mice
The damage caused by fluorosis is permanent, and has been recognized as a public health problem in a number of regions of the world. Although multiple studies provided evidence that sodium fluoride (NaF) elicits adverse effects on reproductive function, the effect of fluoride on female germ cell development is not
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