Abstract
Objective: To study the effect of excessive fluoride intake on the function of pancreatic islet’s B cells.
Methods: We performed x-rays, determined the [F] in the urine, conducted OGTT insulin and C-peptide releasing tests in the serum, and analyzed the drinking water quality of the exposed group and control group.
Results: (1) The [F] in drinking water and the geometrical mean of the [F] in the urine of the people of the exposed group were higher than those of the control group. (2) The fasting blood glucose concentration and the peak value after oral glucose in the exposed group were higher than those of the control group. The peak value was found later in the exposed group than in the control group. (3) The detectable rate of Diabetes and IGT in the exposed group was higher than that in the control group. (4) The blood-insulin and C-peptide in the exposed group were lower than in the control group, although the peak value after oral glucose was found later in the exposed group.
Conclusions: Excessive fluoride can do much harm to the function of the pancreas islet B cells and the effects change with the degree of fluorosis.
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Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride
With half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated total F intake: 4.0 mg F/kg bw/day). After 42 days, determinations were made of the
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Comparative study of the effect of sodium fluoride and sodium monofluorophosphate on glucose homeostasis in the rat.
The effect of acute and chronic administration of sodium fluoride (NaF) or sodium monofluorophosphate (MFP) on the glucose homeostasis of the rat are compared. The oral administration of a single dose of 40 mumol/100 g b.w. of either compound produced similar increases in plasma glucose (up to 1.8 g/l) and
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Toxicity of fluoride to diabetic rats
SUMMARY: Wistar rats were given 20 ppm fluoride in drinking water, or single administration of 115 mg/kg alloxan i.m. to induce diabetes, or single administration of 115 mg/kg alloxan i.m. followed by 20 ppm fluoride for 31 days. Blood sugar level increased in rats given alloxan and alloxan + fluoride.
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Effect of F on rat serum insulin levels in vivo
Several investigators have shown an acute administration of NaF in rats can induce a hyperglycemia. The current study was undertaken to determine if acute injections of NaF would alter the serum insulin levels since LIN et al., Horm. Metab. Res 8, 353-358, 1976 had shown that NaF could inhibit the
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Inhibitory effect of fluoride on the secretion of insulin.
The oral administration of sodium fluoride (NaF) (40 mumol/100 body weight [bw]) to fasting rats produced an immediate fall in insulin levels and the consequent increase in glycemia. These phenomena were observed with plasma fluoride concentrations 5-15 microM. Glycemia and insulin returned to normal levels within 4-5 hours, together with
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