Abstract

Objective: To study the effect of excessive fluoride intake on the function of pancreatic islet’s B cells.

Methods: We performed x-rays, determined the [F] in the urine, conducted OGTT insulin and C-peptide releasing tests in the serum, and analyzed the drinking water quality of the exposed group and control group.

Results: (1) The [F] in drinking water and the geometrical mean of the [F] in the urine of the people of the exposed group were higher than those of the control group.  (2) The fasting blood glucose concentration and the peak value after oral glucose in the exposed group were higher than those of the control group.  The peak value was found later in the exposed group than in the control group.  (3) The detectable rate of Diabetes and IGT in the exposed group was higher than that in the control group.  (4) The blood-insulin and C-peptide in the exposed group were lower than in the control group, although the peak value after oral glucose was found later in the exposed group.

Conclusions:  Excessive fluoride can do much harm to the function of the pancreas islet B cells and the effects change with the degree of fluorosis.

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