Abstract
In the city of Antigo, Wisconsin, fluoridation of the public water supplies was initiated in 1949. ·It was discontinued in November 1960, and reinstituted in October 1965, A striking increase in the rate of deaths from heart disease occurred. in Antigo hnmediately following the introduction of fluoridation in 1949 and following its resumption in 1965. This trend was also evident when the death rates from heart disease in Antigo were compared with those of the United States as a whole. Among older individuals, the rise in mortality after initiation of fluoridation was much higher than among younger people.
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Sodium fluoride induces apoptosis in H9c2 cardiomyocytes by altering mitochondrial membrane potential and intracellular ROS level
Chronic excessive fluoride intake is known to be toxic, and effects of long-term fluorosis on different organ systems have been examined. However, there are few studies about the effects of fluorosis on cardiovascular systems. Here, we studied the fluoride-induced apoptosis in H9c2 cells and determined the underlying molecular mechanisms including
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Changes of the heart muscle due to chronic fluorosis. Part 1: Electrocardiogram and cardiac x-rays in inhabitants of a high fluoride zone
1) The author examined inhabitants of a high fluoride zone (Shionoe village, Kagawa Prefecture, and Odani villAge, Sanyo town, Okayama Prefecture). ln residents of these zones , greater myocardial damage was detected electrocardiographically and dilatation of the cardiac sillouette roentgenograpbically than in n0n-fluoride areas. 2) The myocardial damage appears to
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Intentional Toxic Ingestion of Sodium Fluoride: A Case Report.
Abstract Sodium fluoride is an accessible and frequently used compound that if ingested can cause ventricular dysrhythmias, hemorrhage, and death. We present a case report of a 21-year-old female who presented following an intentional ingestion of a lethal dose of sodium fluoride, developing massive hemorrhage and cardiac arrest. Keywords: sodium fluoride, toxic ingestion, gastrointestinal
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Indoor air quality and health: Empirical evidence from fluoride pollution in China.
Highlights Burning high-fluoride-content coal indoors is the primary source of fluoride pollution in Guizhou Province of China. We apply individual fixed effect models to examine the effects of whether households use coal as domestic fuel. Fluoride pollution from coal burning significantly increases the blood pressure levels and the likelihood of
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Longitudinal associations between early-life fluoride exposures and cardiometabolic outcomes in school-aged children.
Highlights • We evaluated longitudinal associations between repeated fluoride measures and cardiometabolic outcomes in children. • Dietary fluoride altered levels of lipids, adipokines, and diabetes-related biomarkers in children during 4–8 years of age. • Dietary fluoride increased zBMI and odds of overweight/obesity status in children at age 8. • Fewer, though
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Fluoride, Blood Pressure and Hypertension
Individuals with blood pressure readings that exceed 140/90 are considered hypertensive. Hypertension can increase the risk of stroke, heart attack, heart failure, aortic aneurysms, and peripheral arterial disease. An association between increased fluoride in ground water and increased prevalence of hypertension has been observed, especially among adult males (Amini et
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Fluoride & Arteriosclerosis
Healthy arteries are flexible and elastic, allowing efficient transfer of blood and nutrients from the heart to the rest of the body. Arteriosclerosis refers to a stiffening of the arteries, including loss of elasticity. This is a slow, progressive disease that may begin early in life from damage to the
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Fluoride & Arterial Calcification
The major change involved with cardiovascular disease is development of atherosclerosis in critical arteries, which is partially characterized by vascular calcification. The level of coronary artery calcification is thought to be the most important indicator of future cardiovascular events. Increased arterial calcifications have frequently been reported in those with skeletal fluorosis
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Fluoride & Myocardial Damage
Structural damage to the heart resulting from fluoride toxicity has been observed in numerous human and animal studies. The general features of this damage include cloudy swelling, vacuolization or vacuolar degeneration, hemorrhages, interstitial edema, fibrous necrosis, dissolution of nuclei, and thickening of the vessel walls in the heart muscle (Basha
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Fluoride & Electrocardiogram Abnormalities
An electrocardiogram (ECG) is a diagnostic test that measures the electrical activity of the heart. An ECG can reveal heart rate, heart rhythym (i.e. steady or irregular), and the strength and timing of the heart’s natural electrical signals. ECGs are described in terms of “waves” (e.g. amplitude and duration). Problems
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