Abstract
In the city of Antigo, Wisconsin, fluoridation of the public water supplies was initiated in 1949. ·It was discontinued in November 1960, and reinstituted in October 1965, A striking increase in the rate of deaths from heart disease occurred. in Antigo hnmediately following the introduction of fluoridation in 1949 and following its resumption in 1965. This trend was also evident when the death rates from heart disease in Antigo were compared with those of the United States as a whole. Among older individuals, the rise in mortality after initiation of fluoridation was much higher than among younger people.
-
-
Histopathology of myocardial damage in experimental fluorosis in rabbits
Young albino rabbits were administered 5, 10, 20, and 50 mg of sodium fluoride/kg body weight/day subcutaneously for 3.5 months. The control animals were given 1 mL of double distilled water/kg body weight/day. In the fluoridated rabbits, the myocardium showed cloudy swellings, sarcoplasmic vacuolization, and small hemorrhages followed by fibrous
-
Fluoride-induced hyperkalemia: the role of Ca2+-dependent K+ channels.
Acute fluoride poisoning is associated with sudden cardiac death by an unknown mechanism. Because F- binds to Ca2+ to cause marked hypocalcemia, lowered serum Ca2+ concentrations have been thought to be a major underlying factor in the ventricular irritability of F(-)-toxic patients. However, correction of the hypocalcemia does not prevent
-
The pathophysiological profile of the acute cardiovascular toxicity of sodium fluoride.
The mechanism of sodium-fluoride (7681494) cardiovascular toxicity was examined. Spontaneously breathing or mechanically ventilated male Wistar-rats instrumented with carotid and aorta arterial transducers and thermistors were infused intravenously with 2mg/kg per minute (min) sodium-fluoride until death. Arterial blood pressure, heart rate, cardiac output, peripheral resistance, respiration frequency, oxygen consumption (VO2),
-
Changes of certain oxidative, anti-oxidative and vascular function indexes of New Zealand rabbit exposed by high-fluoride.
OBJECTIVE: To observe certain changes of oxidation, anti-oxidation and vascular function indexes of Application of New Zealand rabbit exposed by high-fluoride. METHODS: 20 male New Zealand rabbits were randomly divided into control group, drunk deionized water and feed basic diet. High-fat group, drunk deionized water and feed basic diet plus 0.5%
-
Acute fluoride exposure alters myocardial redox and inflammatory markers in rats.
Acute fluoride (F-) exposure adversely impairs cardiac functions. We previously reported that acute F- toxicity causes modulation in oxidant and antioxidant systems, heat shock proteins, cytoskeletal proteins and AMPK signaling proteins in the myocardium of rats. With these findings, we hypothesized that acute F- intoxication may trigger an acute myocardial
Related Studies :
-
-
-
Fluoride & Electrocardiogram Abnormalities
An electrocardiogram (ECG) is a diagnostic test that measures the electrical activity of the heart. An ECG can reveal heart rate, heart rhythym (i.e. steady or irregular), and the strength and timing of the heart’s natural electrical signals. ECGs are described in terms of “waves” (e.g. amplitude and duration). Problems
-
Fluoride & Arterial Calcification
The major change involved with cardiovascular disease is development of atherosclerosis in critical arteries, which is partially characterized by vascular calcification. The level of coronary artery calcification is thought to be the most important indicator of future cardiovascular events. Increased arterial calcifications have frequently been reported in those with skeletal fluorosis
-
Fluoride, Blood Pressure and Hypertension
Individuals with blood pressure readings that exceed 140/90 are considered hypertensive. Hypertension can increase the risk of stroke, heart attack, heart failure, aortic aneurysms, and peripheral arterial disease. An association between increased fluoride in ground water and increased prevalence of hypertension has been observed, especially among adult males (Amini et
-
Fluoride & Myocardial Damage
Structural damage to the heart resulting from fluoride toxicity has been observed in numerous human and animal studies. The general features of this damage include cloudy swelling, vacuolization or vacuolar degeneration, hemorrhages, interstitial edema, fibrous necrosis, dissolution of nuclei, and thickening of the vessel walls in the heart muscle (Basha
-
Fluoride & Arteriosclerosis
Healthy arteries are flexible and elastic, allowing efficient transfer of blood and nutrients from the heart to the rest of the body. Arteriosclerosis refers to a stiffening of the arteries, including loss of elasticity. This is a slow, progressive disease that may begin early in life from damage to the
Related FAN Content :
-