Abstract

In the electrocardiogram of rabbits given sodium fluoride orally, a pattern of myocardial damage was observed, namely depressed ST, inverted T, prolonged QT interval, multifocal ventricular premature contraction, bundle branch block, and pulmonary P. Histologically, regressive degeneration, cellular infiltration, hyperemia, hemorrhages and thickening of vessel wall were noted in the heart muscle.

• Related Studies :

  • [Experimental study on rat cardiac toxicity induced by sodium fluoride of different dosages].

    The cardiotoxic effect of various dosage of sodium fluoride was investigated. Three-week-old male Wistar rats were fed on normal fodder and distilled water containing different dosages (0, 25, 50, 100 and 150 mg/litre) of sodium fluoride for 6 months to establish an animal model of chronic fluorosis. Electrocardiogram (ECG) was

  • Analyses of ECGs in 271 cases with dental fluorosis

    Our team performed investigations in Yuqing Village and Guanfang Village (1) which were seriously affected by endemic fluorosis, from September to October 1985; those two villages are only 1,500 meters distant from Mangbu District of Zhenxiong County, and the life and production conditions in these two villages are similar to

  • Acute fluoride exposure alters myocardial redox and inflammatory markers in rats.

    Acute fluoride (F-) exposure adversely impairs cardiac functions. We previously reported that acute F- toxicity causes modulation in oxidant and antioxidant systems, heat shock proteins, cytoskeletal proteins and AMPK signaling proteins in the myocardium of rats. With these findings, we hypothesized that acute F- intoxication may trigger an acute myocardial

  • Chronic fluoride toxicity and myocardial damage: antioxidant offered protection in second generation rats

    This experiment was designed to investigate the extent of peroxidative changes and histological alterations in the myocardium of rats exposed to high fluoride for two generations, in addition to ameliorative role of selenium and vitamin E on the above indices. Adult albino Wistar rats were given fluoride through drinking water

  • Effects of sodium fluoride on the electrocardiogram of male rabbits

    Effects of fluoride (F) on electrocardiogram (ECG) values were determined in ten healthy adult male New Zealand white rabbits. After the initial ECG values were measured, the rabbits were administered 20 mg NaF/kg body weight by oral intubation for two months, and the new ECG values were determined. There was

• Related FAN Content :

  • Fluoride & Arteriosclerosis

    Healthy arteries are flexible and elastic, allowing efficient transfer of blood and nutrients from the heart to the rest of the body. Arteriosclerosis refers to a stiffening of the arteries, including loss of elasticity. This is a slow, progressive disease that may begin early in life from damage to the

  • Fluoride & Myocardial Damage

    Structural damage to the heart resulting from fluoride toxicity has been observed in numerous human and animal studies. The general features of this damage include cloudy swelling, vacuolization or vacuolar degeneration, hemorrhages, interstitial edema, fibrous necrosis, dissolution of nuclei, and thickening of the vessel walls in the heart muscle (Basha

  • Fluoride, Blood Pressure and Hypertension

    Individuals with blood pressure readings that exceed 140/90 are considered hypertensive. Hypertension can increase the risk of stroke, heart attack, heart failure, aortic aneurysms, and peripheral arterial disease. An association between increased fluoride in ground water and increased prevalence of hypertension has been observed, especially among adult males (Amini et

  • Fluoride & Arterial Calcification

    The major change involved with cardiovascular disease is development of atherosclerosis in critical arteries, which is partially characterized by vascular calcification. The level of coronary artery calcification is thought to be the most important indicator of future cardiovascular events. Increased arterial calcifications have frequently been reported in those with skeletal fluorosis

  • Fluoride & Electrocardiogram Abnormalities

    An electrocardiogram (ECG) is a diagnostic test that measures the electrical activity of the heart. An ECG can reveal heart rate, heart rhythym (i.e. steady or irregular), and the strength and timing of the heart’s natural electrical signals. ECGs are described in terms of “waves” (e.g. amplitude and duration). Problems