Abstract
In a prospective case controlled study, we evaluated the adverse effects of long-term fluoride ingestion on the gastrointestinal tract. Ten patients with otosclerosis who were receiving sodium fluoride 30 mg/day for a period of 3-12 months, and 10 age- and sex-matched healthy volunteers were included. They were all evaluated clinically and subjected to a real time ultrasound examination, upper gastrointestinal endoscopy, and biopsies from the gastric antrum and duodenum. The biopsies were subjected to a rapid urease test as well as light and electron microscopic examinations. Ionic fluoride was estimated in the serum, urine, and drinking water using an ION 85 Ion Analyzer. Seven subjects (70%) ingesting fluoride had abdominal pain, vomiting, and nausea. Petechiae, erosions, and erythema were seen on endoscopy in all the subjects, but not in the controls. Histological examination of the gastric antral biopsy showed chronic atrophic gastritis in all the subjects but in only one (10%) healthy volunteer. Scanning electron microscopic examination showed “cracked-clay” appearance, scanty microvilli, surface abrasions, and desquamated epithelium in the subjects ingesting fluoride, but not in the controls. We conclude that long-term fluoride ingestion is associated with a high incidence of dyspeptic symptoms as well as histological and electron microscopic abnormalities.
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[Effect of gastric mucosa in fluorosis and arsenic-fluorosis].
Gastroscopy to 35 patients with fluorosis, 32 with arsenic-fluorosis, and 25 control had been performed to study the influence of fluorosis on arsenic-fluorosis on the gastric mucosa. There was significant difference on gradient and activity of chronic gastritis among the three groups, but there was no significant difference in the
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Environmental fluoride exposure disrupts the intestinal structure and gut microbial composition in ducks.
Highlights Intestinal structure and gut microbial composition and diversity depends on various animal and environment related factors. Fluoride and its compounds can accumulate in animals and plants and threaten public health through the food chain. Simple and electron microscopy coupled with 16S rRNA sequencing revealed that excessive fluoride exposure can
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Safety of osteoporosis treatment with sodium fluoride, calcium phosphate and vitamin D.
During an 8-year period, 163 consecutive patients with spinal crush fracture osteoporosis started a 5-year treatment with a combination of sodium fluoride (60 mg/day), calcium phosphate (45 mmol/day) and vitamin D2 (18,000 IU/day), and were followed in the outpatient clinic every 3 months. Fourty-three patients completed the 5-year treatment. Mean
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Prevalence of endemic fluorosis with gastrointestinal manifestations in people living in some North-Indian villages
Numerous reports on epidemiological surveys of skeletal and dental fluorosis exist, but information is quite limited on non-skeletal manifestations of fluoride toxicity. The present study was conducted to assess the prevalence and severity of non-skeletal manifestations, especially gastrointestinal disturbances, in an area o skeletal and dental fluorosis. The subjects, numbering 1958
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Intestinal changes associated with fluoride exposure in rats: Integrative morphological, proteomic and microbiome analyses.
Highlights Fluoridated water increases the thickness of the ileum wall. Fluoridated water increases CGRP-IR and SP-IR varicosities in the ileum. Proteomic changes induced by fluoride have similarity with Crohn’s disease. Microbiomic changes induced by fluoride are associated with inflammation. Abstract Gastrointestinal signs and symptoms are the first signs of toxicity due
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Fluoride & Gastrointestinal System: The Importance of Fluoride Concentration in Stomach
The following is an excerpt from the National Research Council's (2006) review of fluoride toxicity: "It is important to realize that GI effects depend more on the net concentration of the aqueous solution of fluoride in the stomach than on the total fluoride dose in the fluid or solid ingested. The
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Gastrointestinal Problems Among Individuals with Skeletal Fluorosis
Humans suffering from skeletal fluorosis are known to suffer from an increased occurrence of gastrointestinal disorders. When fluoride intake is reduced, these gastrointestinal problems are among the first symptoms to disappear. The following are some of the studies that have examined this issue: "It is clear from the observations presented in this article
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Side Effects from Fluoride Gels: Gastric Distress
Gastric distress -- including nausea, pain, and vomiting -- is one the most common side effects from professional application of "fluoride gels" at the dentist. Patients receiving fluoride gels can swallow more than 20 mg of fluoride from a single treatment -- doses that far exceed the doses that can
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Fluoride-Induced Damage to Gastric Mucosa in Human Clinical Trials
When fluoride has been used (at doses of 18-34 mg/day) as an experimental treatment for osteoporosis, gastric pain is one of the two main side effects consistently encountered. To better understand how fluoride causes this effect, researchers have sought to determine how fluoride affects the tissue that lines the gastrointestinal tract. In a
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Fluoride-Induced Gastric Symptoms in Human Clinical Trials
In studies where fluoride has been used (at doses of 18-34 mg/day) as an experimental drug for the treatment of osteoporosis, gastrointestinal disturbances are one of the two main side effects consistently encountered. The following are some of the accounts from the published literature: "The use of fluoride in the prophylaxis or
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