Abstract
Evidence is presented that accumulation of cAMP in isolated rat thoracic aorta and diaphragm is stimulated by several fluorine containing compounds (NaF, Na2PO3F (MFP) and SnF2). Time course experiments with NaF showed that maximal stimulation of cAMP accumulation was observed within 2.5 min. NaF and MFP produced significant increases in cAMP accumulation at concentrations of 0.1 microM and SnF2 produced a significant increase at 0.01 microM. The sensitivity of these tissues to the fluorine compounds is similar to that previously reported (Curro and Mickunas, 1981) for the inhibition of norepinephrine induced contractions by fluorine compounds in isolated thoracic aorta.
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Fluoride stimulates in vitro vascular prostacyclin synthesis: interrelationship of G proteins and protein kinase C
The role of G proteins in mediating adrenoceptor-prostacyclin synthesis coupling was investigated using the G protein activator, sodium fluoride. Sodium fluoride (NaF) stimulated in vitro rat aortic prostacyclin (PGI2) synthesis (EC50 = 5 x 10(-3) mol.l-1), an action inhibited completely by the presence of EDTA (10(-2) mol.l-1). The NaF-PGI2 dose-response
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The effects of fluoridated water on rat urine and tissue cAMP levels
Male Wistar rats were fed a fluoride deficient diet (less than 0.5 parts/10(6) F), and either distilled water or fluoridated water (1.0 parts/10(6)). By week 3, the control group had urinary excretions of 106 +/- 5 nmol cAMP/day (mean +/- SEM) whereas the experimental group excreted 129 +/- 6 nmol
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Fluoride stimulation of slow Ca2+ current in cardiac muscle.
Fluoride, a known activator of the adenylate cyclase in broken-cell preparations of heart and other tissue [21, 22] was tested for its ability to act as a positive inotropic agent in cardiac muscle and for its ability to concomitantly induce Ca2+ channels. The induction of slow Ca2+ channels was tested
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Further evidence for the involvement of cAMP in central blood pressure regulation
In order to test the hypothesis that the activity of cardiovascular centres is determined by their content of cAMP a number of drugs which influence the activity of either phosphodiestase or adenylcyclase were injected in doses of 100-1000 mug/kg into the lateral cerebral ventricle of cats. The effects on blood
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Cardiovascular dysfunction and oxidative stress following human contamination by fluoride along with environmental xenobiotics (Cd & Pb) in the phosphate treatment area of Togo, West Africa.
Highlights The exposure of the population is important in relation to the routes of exposure levels of pollutants. Cd, Pb and F in human blood are high in subjects living in and around the phosphate processing plant. The variation of the biochemical indicators indicating the risk of cardiovascular diseases. The
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Fluoride & Myocardial Damage
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Fluoride & Electrocardiogram Abnormalities
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Fluoride, Blood Pressure and Hypertension
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Fluoride & Arterial Calcification
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