Abstract
Young albino rabbits were administered 5, 10, 20, and 50 mg of sodium fluoride/kg body weight/day subcutaneously for 3.5 months. The control animals were given 1 mL of double distilled water/kg body weight/day. In the fluoridated rabbits, the myocardium showed cloudy swellings, sarcoplasmic vacuolization, and small hemorrhages followed by fibrous necrosis. The degenerative changes were most pronounced in animals treated with 50 mg of sodium fluoride/kg body weight/day. The myocardium exhibited fibrous necrosis, dissolution of nuclei, fibrillolysis, extensive vacuole formation and interstitial cells in the connective tissue. The degree of myocardial damage seemed to be directly proportional to the dosage of fluoride administered. In the control animals, the myocardium showed normal structure without any of the changes mentioned above.
-
-
Ca2+ metabolic disorder and abnormal expression of cardiac troponin involved in fluoride-induced cardiomyocyte damage.
Highlights F induced cardiomyocyte damage. F induced Ca2+ metabolic disorder. F inhibited the expression of cardiac troponin. F induced ultrastructure damage in cardiomyocytes. F interfered with production of ATP in cardiomyocytes. Our previous study indicated that excessive fluoride (F) induces ATP5J and ATP5H proactive expression by interfering cardiomyocyte mitochondrial dysfunction in
-
ITRAQ-based proteomics reveals the potential mechanism of fluoride-induced myocardial contraction function damage.
Highlights Pressure-volume loop analysis highlighted the impaired effects of fluoride exposure on cardiac function and myocardial contraction indicators. Histological analysis of rat heart tissue under fluoride exposure revealed extensive damage. Proteomics analysis highlighted effects on the myocardial contraction pathway. Protein network analysis highlighted the key roles of RyRs, Tpm and
-
Comparative proteomics analysis of cardiac muscle samples from pufferfish Takifugu rubripes exposed to excessive fluoride: initial molecular response to fluorosis
Comparative proteomics was performed to identify proteins in the cardiac muscle of Takifugu rubripes in initial response to excessive fluoride. Sixteen fish were randomly divided into a control group and an experimental group. The control group was raised in softwater alone (F(-) = 0.4 mg/L), and the experimental group was
-
Rutin potentially attenuates fluoride induced oxidative stress mediated cardiotoxicity, blood toxicity and dyslipidemia in rats
The present study was undertaken to evaluate cardio protective effect of rutin against sodium fluoride-induced oxidative stress mediated cardio toxicity and blood toxicity. Cardiac injury was induced by daily administration of sodium fluoride 600ppm in distilled water for 4 weeks. The animals exposed to NaF exhibited a significant increase in
-
Possible protective role of calcium against fluoride induced cardio toxicities in adult male albino rats
Fluoride contamination in drinking water due to natural and anthropogenic activities has been recognized as one of the major problems worldwide imposing a serious threat to human health. Excessive exposure to fluoride appears to be serious and causes metabolic, functional and structural damages in many organs especially in the heart.
Related Studies :
-
-
-
Fluoride & Myocardial Damage
Structural damage to the heart resulting from fluoride toxicity has been observed in numerous human and animal studies. The general features of this damage include cloudy swelling, vacuolization or vacuolar degeneration, hemorrhages, interstitial edema, fibrous necrosis, dissolution of nuclei, and thickening of the vessel walls in the heart muscle (Basha
-
Fluoride & Arteriosclerosis
Healthy arteries are flexible and elastic, allowing efficient transfer of blood and nutrients from the heart to the rest of the body. Arteriosclerosis refers to a stiffening of the arteries, including loss of elasticity. This is a slow, progressive disease that may begin early in life from damage to the
-
Fluoride & Electrocardiogram Abnormalities
An electrocardiogram (ECG) is a diagnostic test that measures the electrical activity of the heart. An ECG can reveal heart rate, heart rhythym (i.e. steady or irregular), and the strength and timing of the heart’s natural electrical signals. ECGs are described in terms of “waves” (e.g. amplitude and duration). Problems
-
Fluoride & Arterial Calcification
The major change involved with cardiovascular disease is development of atherosclerosis in critical arteries, which is partially characterized by vascular calcification. The level of coronary artery calcification is thought to be the most important indicator of future cardiovascular events. Increased arterial calcifications have frequently been reported in those with skeletal fluorosis
-
Fluoride, Blood Pressure and Hypertension
Individuals with blood pressure readings that exceed 140/90 are considered hypertensive. Hypertension can increase the risk of stroke, heart attack, heart failure, aortic aneurysms, and peripheral arterial disease. An association between increased fluoride in ground water and increased prevalence of hypertension has been observed, especially among adult males (Amini et
Related FAN Content :
-