Abstract
In this study, our objective was to determine blood T3, T4, and TSH levels in rabbits, which were administered fluoride chronically. Twenty one male rabbits were divided into three groups. The rabbits in group I (control), group II and III were administered, respectively, normal drinking water (containing 0.07 ppm fluoride), drinking water containing 10 ppm fluoride and water containing 40 ppm fluoride for 70 days. On the days 21 and 70 blood was taken and plasma T3, T4, TSH and fluoride levels were studied. According to the results obtained a statistically significant increase was observed in the T3 level of the rabbits receiving fluoride at 40 ppm level for 70 days compared with controls, and a statistically significant decrease was detected inT4 level. Plasma fluoride level increased in proportion to the amount and duration of the fluoride administered.
-
-
[The change of thyroid functlon from the children with fluoride aluminum combined toxicosis in Shuicheng Area of Guizhou].
The levels of serum T3, T4 and TSH were analyzed in the children with fluoride aluminum combined toxicosis in Shuicheng area of Guizhou as compared with the children without fluoride-aluminum combined toxicosis. The results showed that serum T4 content decreased in the children with fluoride aluminum combined toxicosis (103.9±15.9 nmol/L
-
Fluoride exposure and indicators of thyroid functioning in the Canadian population: implications for community water fluoridation.
BACKGROUND: There are concerns that altered thyroid functioning could be the result of ingesting too much fluoride. Community water fluoridation (CWF) is an important source of fluoride exposure. Our objectives were to examine the association between fluoride exposure and (1) diagnosis of a thyroid condition and (2) indicators of thyroid
-
Effect of excess fluoride ingestion on human thyroid function in Gaya region, Bihar, India.
Fluoride (F) is mainly ingested through drinking water and food. In addition to producing dental and skeletal fluorosis, excess fluoride may also affect the functioning of many organs including the thyroid gland. The present study investigated the thyroid function of subjects with dental fluorosis from F-endemic areas of Gaya region,
-
Ameliorative effect of resveratrol against fluoride-induced alteration of thyroid function in male wistar rats
Resveratrol (3,4,5-trihydroxystilbene), a polyphenol and well-known natural antioxidant has been evaluated for its protective effect against fluoride-induced metabolic dysfunctions in rat thyroid gland. Fluoride, the most abundant anions present in groundwater throughout the world, creates a major problem in safe drinking water and causes metabolic, structural, and functional injuries in
-
A systematic analysis on possibility of water fluoridation causing hypothyroidism.
Background: Community water fluoridation is widely used worldwide and its role in preventive dental health care is well established. However, there is sufficient evidence of the ill effects of excessive fluoride content in water, causing skeletal and dental fluorosis. Alongside, there was also extraskeletal and dental manifestations of excessive fluorides
Related Studies :
-
-
-
Fluoride's Impact on Thyroid Hormones
Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as
-
NRC (2006): Fluoride's Impact on the Thyroid Gland
Several lines of information indicate an effect of fluoride exposure on thyroid function. It is difficult to predict exactly what effects on thyroid function are likely at what concentration of fluoride exposure and under what circumstances.
-
Fluoride Aggravates Thyroid Damage Caused by Excess Iodine Intake
Chinese researchers have found that the combination of excess fluoride with excess iodine caused greater reductions in IQ, or greater increases in goitre than either scenario by itself.
-
Fluorine in the Aetiology of Endemic Goitre
The distribution of endemic goitre in the Punjab and in England is related to the geological distribution of fluorine and to the distribution of human dental fluorosis (mottled enamel). Inquiry showed the presence of dental fluorosis among school-children in two areas of Somerset where two previous observers had recorded a high incidence of goitre, and the absence of dental fluorosis in an adjoining area selected as control where endemic goitre was absent.
-
Fluoride, Water Hardness, and Endemic Goitre
Variations in goitre prevalence were found to correlate closely with the fluoride content (p=0-74; P<0-01) and with the hardness (p=0.77; P<0-01) of the water in each village. The effects of fluoride and water hardness seem to be independent.
Related FAN Content :
-