Abstract
The effect of 2 months fluoride administration (0.1 and 1.0 mg daily/rat) on thyroxine and triiodothyronine level in blood and T3-resin uptake ratio was investigated in rats. In addition, free thyroxine index was calculated from serum thyroxine level and T3-resin uptake ratio. It was found that fluoride administration caused: 1. decrease in thyroxine and triiodothyronine level in plasma; 2. decrease in free thyroxine index values; 3. Increase in T3-resin uptake ratio. From these observations as well as from previous experiments it was concluded that fluoride given continuously to the rats may influence the thyroid gland rather indirectly by changing thyroid hormone transportation in the blood.
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Fluorine and thyroid gland function: a review of the literature
The increasing use of fluoride for prevention of dental caries poses the problem as to whether this halogen has antagonistic properties towards iodine, whereby it could hamper the success of iodine prophylaxis of endemic goitre. Review of the literature shows that some authors have found an inhibition by fluoride of
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Effect of excessive green tea versus fluoride and caffeine on body weight and serum thyroid hormones in male mice
Green tea is a worldwide used beverage rich in fluoride and caffeine. To study the effect of excessive green tea intake versus fluoride and caffeine on body weight and serum thyroid hormones in male mice. Also, to confirm the effect of excessive green tea intake on thyroid gland was due
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Effects of high iodine and high fluorine on children’s intelligence and thyroid function.
Objective: Try to find out the effects of high iodine and high fluorine on children’s intelligence and thyroid function. Methods: We selected in Qingyun County the Lidian Primary School, where the iodine and fluorine in the water are relatively high in concentration as the investigative point and Dading Primary School where the iodine and
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[An investigation on the serum thyroid hormones and fluoride concentrations in patients with endemic fluorosis].
Endemic fluorosis is a systematic disease. We investigated the serum free fluoride, thyroid hormones and TSH concentrations in 37 cases. Significantly lowered serum T4 and T3 and increased TSH were found in patients. Patients' serum rT3 concentrations were not significantly different from the controls. Significant negative correlations were found between
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Clinical and biochemical profile of deiodinase enzymes and thyroid function hormones in patients of fluorosis
The thyroid involvement is very significant feature of fluorosis due to fluoride accumulation in soft tissues. The participation of long term consumption of fluoride in drinking water on thyroid hormone status and deiodinating enzymes in fluorotic patients selected randomly from various parts of fluoride endemic areas, was elucidated. Type I
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Fluoride's Impact on Thyroid Hormones
Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as
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The Relationship Between Fluoride Exposure & Goitre in South Africa
As a general rule simple goitre, irrespective of the cause, can be very, or fairly, satisfactorily combated by an adequate increase in man's daily iodine intake, except when the enlargement of the gland is due to the ingestion of excessive amounts of fluorine. The only correct solution to fluorine-induced endemic goitre is the removal of this element from the drinking water.
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NRC (2006): Fluoride's Impact on the Thyroid Gland
Several lines of information indicate an effect of fluoride exposure on thyroid function. It is difficult to predict exactly what effects on thyroid function are likely at what concentration of fluoride exposure and under what circumstances.
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Fluorine in the Aetiology of Endemic Goitre
The distribution of endemic goitre in the Punjab and in England is related to the geological distribution of fluorine and to the distribution of human dental fluorosis (mottled enamel). Inquiry showed the presence of dental fluorosis among school-children in two areas of Somerset where two previous observers had recorded a high incidence of goitre, and the absence of dental fluorosis in an adjoining area selected as control where endemic goitre was absent.
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Fluoride Aggravates Thyroid Damage Caused by Excess Iodine Intake
Chinese researchers have found that the combination of excess fluoride with excess iodine caused greater reductions in IQ, or greater increases in goitre than either scenario by itself.
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