Abstract
The effect of 2 months fluoride administration (0.1 and 1.0 mg daily/rat) on thyroxine and triiodothyronine level in blood and T3-resin uptake ratio was investigated in rats. In addition, free thyroxine index was calculated from serum thyroxine level and T3-resin uptake ratio. It was found that fluoride administration caused: 1. decrease in thyroxine and triiodothyronine level in plasma; 2. decrease in free thyroxine index values; 3. Increase in T3-resin uptake ratio. From these observations as well as from previous experiments it was concluded that fluoride given continuously to the rats may influence the thyroid gland rather indirectly by changing thyroid hormone transportation in the blood.
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Impact of Drinking Water Fluoride on Human Thyroid Hormones: A Case- Control Study.
The elevated fluoride from drinking water impacts on T3, T4 and TSH hormones. The aim was study impacts of drinking water fluoride on T3, T4 and TSH hormones inYGA (Yazd Greater Area). In this case- control study 198 cases and 213 controls were selected. Fluoride was determined by the SPADNS
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Thyroid dysfunction associated with excess fluoride intakes: scope for primary prevention
Background: Preventable thyroid dysfunction has remained a neglected entity worldwide. Excess fluoride consumption over years leads to irreversible thyroid dysfunction. Materials and Methods: Subjects (N = 275) with thyroid dysfunction were recruited from medicine and endocrinology OPDs/wards and were thoroughly examined. The source and type of water consumed by these subjects
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A comparative study of fluoride ingestion levels, serum thyroid hormone & TSH level derangements, dental fluorosis status among school children from endemic and non-endemic fluorosis areas
The study was undertaken to determine serum/urinary fluoride status and comparison of free T4, free T3 and thyroid stimulating hormone levels of 8 to 15 years old children with and without dental fluorosis living in an endemic and non-endemic fluorosis area. A sample group of 60 male and female school children,
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Is water fluoridation a hidden cause of obesity? Histological study on thyroid follicular cells of albino rats
Introduction: Fluoride in drinking water is known to exert both beneficial and detrimental effects on health. When consumed in excess, it is known to cause adverse effects including dental fluorosis, hip fracture, bone cancer, lower intelligence, and kidney toxicity plus goiter. Aim: This study was carried out to determine the histological
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Effects of high fluoride and low iodine on thyroid function in offspring rats
Thirty-two Wistar rats were divided randomly into four groups of eight with six females and two males in each group. The rats were exposed to high fluoride drinking water (45 mg F- L-1 from 100 mg NaF L-1), low dietary iodine (0.0855 mg kg-1), or both together in order to
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Fluoride's Impact on Thyroid Hormones
Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as
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Fluoride, Water Hardness, and Endemic Goitre
Variations in goitre prevalence were found to correlate closely with the fluoride content (p=0-74; P<0-01) and with the hardness (p=0.77; P<0-01) of the water in each village. The effects of fluoride and water hardness seem to be independent.
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Fluoride Aggravates Thyroid Damage Caused by Excess Iodine Intake
Chinese researchers have found that the combination of excess fluoride with excess iodine caused greater reductions in IQ, or greater increases in goitre than either scenario by itself.
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Fluoride Exposure Aggravates the Impact of Iodine Deficiency
A consistent body of animal and human research shows that fluoride exposure worsens the impact of an iodine deficiency. Iodine is the basic building block of the T3 and T4 hormones and thus an adequate iodine intake is essential for the proper functioning of the thyroid gland. When iodine intake is inadequate during infancy and
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The Relationship Between Fluoride Exposure & Goitre in South Africa
As a general rule simple goitre, irrespective of the cause, can be very, or fairly, satisfactorily combated by an adequate increase in man's daily iodine intake, except when the enlargement of the gland is due to the ingestion of excessive amounts of fluorine. The only correct solution to fluorine-induced endemic goitre is the removal of this element from the drinking water.
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