Abstract

212 Wistar rats were divided randomly into five groups, each of which was fed on one of the following regimes: (1) Normal iodine and fluorine; (2) normal iodine, 10 ppm fluorine; (3) normal iodine, 30 ppm fluorine; (4) now iodine, normal fluorine; (5) low iodine, 10 ppm fluorine. The experiment lasted seven months. The results showed that severe morphologic and functional damage of the· thyroid appeared in the rats drinking water containing 30 ppm fluonne, but only slight abnormal ultrastructural changes of’ thyroid cells appeared in rats drinking water containing 10 ppm fluorine; rats with iodine deficiency showed proliferative changes of the thyroid; rats on iodine deficient diet and drinking water containing 10 ppm fluorine showed morphologic and functional damage as well as proliferation. The study suggests that there is synergistic action of iodine deficiency and fluorine intoxication on the thyroid.

• Related Studies :

  • DNA damage in thyroid gland cells of rats exposed to long-term intake of high fluoride and low iodine.

    Thirty-two one-month-old Wistar albino rats were divided randomly into four equal groups of eight (female:male = 3:1). To assess damage to DNA in their thyroid gland cells, the first group (1) of rats served as the untreated control, the second group (2) was administered a high concentraiton of fluoride (HiF,

  • Long-term effects of various iodine and fluorine doses on the thyroid and fluorosis in mice

    OBJECTIVE: To elucidate the participation of the independent and combined long term effect of various concentrations of iodine and fluorine on the pathogenesis of goiter and fluorosis in mice. METHODS: Nine drinking water supplies with different iodine and fluorine content were prepared by combination of potassium iodate and sodium fluoride solutions in bidistilled

  • The specific features of the development of iodine deficiencies in children living under environmental pollution with fluorine compounds.

    Characteristics of the development of iodine-deficient states in children growing up in conditions of contamination of the surrounding environment with fluoride compounds. It is known that in the presence of insufficient function of the thyroid gland a whole spectrum of pathologic conditions develops known at the present time as “iodine-deficiency diseases.” 

  • The effects and underlying mechanism of excessive iodide on excessive fluoride-induced thyroid cytotoxicity

    In many regions, excessive fluoride and excessive iodide coexist in groundwater, which may lead to biphasic hazards to human thyroid. To explore fluoride-induced thyroid cytotoxicity and the mechanism underlying the effects of excessive iodide on fluoride-induced cytotoxicity, a thyroid cell line (Nthy-ori 3-1) was exposed to excessive fluoride and/or excessive

  • The effects of high levels of fluoride and iodine on intellectual ability and the metabolism of fluoride and iodine.

    The authors carried out a study on the intellectual abilities and fluoride/iodine metabolism of children living in a high fluoride-high iodine area. Among the results: the percentage of the general population living in this fluoride/iodine-contaminated region that suffered from goiter (clinical thyroid enlargement) was 3.8%, the rate of children already showing some thyroid

• Related FAN Content :

  • The Relationship Between Fluoride Exposure & Goitre in South Africa

    As a general rule simple goitre, irrespective of the cause, can be very, or fairly, satisfactorily combated by an adequate increase in man's daily iodine intake, except when the enlargement of the gland is due to the ingestion of excessive amounts of fluorine. The only correct solution to fluorine-induced endemic goitre is the removal of this element from the drinking water.

  • Fluoride Exposure Aggravates the Impact of Iodine Deficiency

    A consistent body of animal and human research shows that fluoride exposure worsens the impact of an iodine deficiency. Iodine is the basic building block of the T3 and T4 hormones and thus an adequate iodine intake is essential for the proper functioning of the thyroid gland. When iodine intake is inadequate during infancy and

  • Fluoride, Water Hardness, and Endemic Goitre

    Variations in goitre prevalence were found to correlate closely with the fluoride content (p=0-74; P<0-01) and with the hardness (p=0.77; P<0-01) of the water in each village. The effects of fluoride and water hardness seem to be independent.

  • Fluorine in the Aetiology of Endemic Goitre

    The distribution of endemic goitre in the Punjab and in England is related to the geological distribution of fluorine and to the distribution of human dental fluorosis (mottled enamel). Inquiry showed the presence of dental fluorosis among school-children in two areas of Somerset where two previous observers had recorded a high incidence of goitre, and the absence of dental fluorosis in an adjoining area selected as control where endemic goitre was absent.

  • Nutrient Deficiencies Enhance Fluoride Toxicity

    It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,