Abstract
The results of analyses of the mineral content of drinking water from three Indian villages with endemic fluorosis surveyed for the incidence of thyroid enlargement are reported.
With the possible exception of temporary thyroid enlargement encountered in pubertal subjects (type b), no relation was found between the incidence of endemic goiter and the fluorine in the water supply.
Excerpt:
With regard to the slight and temporary enlargement of the thyroid encountered in the age group 14-17 (type b), detailed scrutiny of the data . . . reveals that with a fall in mean fluorine content of the water from 10.7 mg/l in Kamaguda to 5.4 mg/l in Yellareddyguda, there was a corresponding progressive fall in the incidence of pubertal goiters from 40% in Kamaguda to 9% in Yellareddyguda, However, associated with the fall in fluorine content there was also a rise in mean iodine of the water. The figures can be interpreted to indicate that, so far as type b goiters are concerned, (1) fluorine may be actually goitrogenic, and (2) high concentrations of iodine may have a goiter-preventing effect. Investigations in other areas, where the variations in fluorine content are not associated with variations in iodine content of the type encountered here, may throw light on this particular problem.
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Endemic goiter associated with high iodine intake in primary school children in the Saharawi Arab Democratic Republic.
The high prevalence of goiter in Saharan children visiting Asturias in the summer prompted us to study the problem in greater depth. Neck palpation was performed in a sample of 570 school children from the Saharawi Arab Democratic Republic. Weight, height, T4, thyroid-stimulating hormone and anti-thyroperoxidase antibodies in capillary blood were
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Prevalence and manifestations of water-born fluorosis among schoolchildren in Kaiwara village of India: a preliminary study
Background: Fluorosis is an endemic condition with prevalence in 19 states and union territories in India. It is an urgent task to survey the fluorosis-related problems in these regions. Objective: To study the clinical manifestations of water-born fluorosis among schoolchildren in Kaiwara village of India. Methods: A cross-sectional study was conducted in
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Fluorine in the aetiology of endemic goitre
MANY different factors leading to relative or absolute deficiency of iodine may cause changes in the thyroid gland. May (1935) found that the administration of fluorine to rats produced hypoplasia of the thyroid epithelium with altered staining reaction of the colloid. Having experimented with over 800 patients, he advocated internal
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Excessive iodine intake, water chemicals and endemic goitre in a Sudanese coastal area
OBJECTIVE: To study the associations between intakes of iodine and water chemicals and the thyroid gland status of schoolchildren living in the coastal city of Port Sudan. DESIGN: In our previous nationwide study on goitre, it was observed that the prevalence of goitre was high in Port Sudan city despite high
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Fluorosis and iodine deficiency disorders in India.
This review focuses on fluorosis and iodine deficiency disorders, two serious, highly prevalent metabolic disorders that are under-reported. These are caused by the two elements of the halogen family, fluorine and iodine. The former in excess and the latter in deficiency are the cause for concern. Excess fluoride (F–) consumption
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Fluorine in the Aetiology of Endemic Goitre
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