An investigation has been carried out on the effects of the intake of small amounts of sodium fluoride on kidney structure and function in rats, with a view to the possibility of establishing some means of testing for the toxic effects of fluorine in human beings, and of demonstrating the existence of a fluorine hazard before such severe intoxication has resulted as to cause disability and obvious skeletal lesions. The effects on kidney function are immediate.
Rats given small amounts of NaF in the diet exhibited, in addition to the well-known skeletal and dental lesions, marked polydipsia and polyuria,
… At autopsy the kidneys were dark, shrunken and nodulated.
Demonstration of alkaline phosphatase showed that there were fibrotic lesions in the cortex, where the enzyme was practically absent owing to absence of functional tubular tissue.
The histological examination indicated that in the kidneys there was a vascular, glomerular and more obviously tubular degeneration leading finally to interstitial fibrosis.
The fluoride-fed rats showed diminished growth, and at low body weights there was a marked diminution of fat stores.
Nitrogen metabolism was greater in the fluoride-fed rats than in the controls.
Introduction The history of anesthesia is a relatively recent one; if one begins with the analgesia dentist, Horace Wells, who discovered the used nitrous oxide during a dental extraction in the early 1800s. The first public showing of anesthesia occurred in October 1846, when ether was used to prevent pain during surgery
Pathological changes in the tissues of rats (albino) and monkeys (macaca radiata) in fluorine toxicosis
1. Stomach, duodenum, small intestine, kidney, liver, spleen, skin, heart, aorta, lungs, brain, pancreas, adrenals, thyroid and parathyroid of rats and monkeys suffering from chronic fluorosis have been histologically examined. 2. Fluorine has not been found to have any effect on the heart muscle, aorta, skin and parathyroids, whereas it has
Significance of Mg-hardness and fluoride in drinking water on chronic kidney disease of unknown etiology in Monaragala, Sri Lanka.
Highlights Geochemistry of groundwater in a CKDu hotspot was investigated as a case-control study. Comparatively higher Mg and fluoride levels were found in affected regions. Excess fluoride and hardness in drinking water could enhance the tubular injury. Nephrotoxic trace elements such as As, Pb, and Cd, etc. were below
Histopathological changes of renal tissue following sodium fluoride administration in two consecutive generations of mice. Correlation with the urinary elimination of fluoride
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[Study on the relationship between renal apoptosis and expression of caspase protein in fluoride induced rat].
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