An investigation has been carried out on the effects of the intake of small amounts of sodium fluoride on kidney structure and function in rats, with a view to the possibility of establishing some means of testing for the toxic effects of fluorine in human beings, and of demonstrating the existence of a fluorine hazard before such severe intoxication has resulted as to cause disability and obvious skeletal lesions. The effects on kidney function are immediate.
Rats given small amounts of NaF in the diet exhibited, in addition to the well-known skeletal and dental lesions, marked polydipsia and polyuria,
… At autopsy the kidneys were dark, shrunken and nodulated.
Demonstration of alkaline phosphatase showed that there were fibrotic lesions in the cortex, where the enzyme was practically absent owing to absence of functional tubular tissue.
The histological examination indicated that in the kidneys there was a vascular, glomerular and more obviously tubular degeneration leading finally to interstitial fibrosis.
The fluoride-fed rats showed diminished growth, and at low body weights there was a marked diminution of fat stores.
Nitrogen metabolism was greater in the fluoride-fed rats than in the controls.
The effect of fluoride on the structure, function, and proteome of a renal epithelial cell monolayer
High concentrations of fluoride in the body may cause toxic effects. Here, we investigated the effects of fluoride on the structure, function, and proteome of a cortical collecting duct epithelium in vitro. Kidney tubule cells (M-1) were chosen because the concentration of fluoride in the kidney is 4-5-fold higher than
Histological and histochemical appearance of livers and kidneys of rats after long-term treatment with different concentrations of sodium fluoride in drinking water
After a review of the controversies in the literature, a histologic and histochemical study of the livers and kidneys of 48 albino rats was performed. The animals were placed on a diet containing 1 ppm NaF in demineralized drinking water, or 1, 10 or 100 ppm NaF in tap water
Chronic toxicity of dietary sodium monofluorophosphate in growing rats, with special reference to kidney changes
Effect of exposure to fluoride and acetaminophen on oxidative/nitrosative status of liver and kidney in male and female rats
BACKGROUND: This study was undertaken to investigate, the effect of 6 weeks treatment with acetaminophen (AAP) and fluoride (F), administered either separately or together, on nitric oxide generation, lipid and protein peroxidation, total antioxidant status and level of reduced glutathione in the liver and kidney of male and female Wistar
Fluoride osteosclerosis from drinking water
1. A case of osteosclerosis, exhibiting in addition mottled enamel, severe anemia showing no response to anti-anemic therapy, and bilateral renal lesions is reported. 2. The diagnosis of fluoride osteosclerosis was proved by the history of a long residence in areas of endemic fluorosis and by fluorine analysis of the patient's
Related Studies :
Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence
A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.
Fluoride as a Cause of Kidney Disease in Humans
Because the kidney is exposed to higher concentrations of fluoride than all other soft tissues (with the exception of the pineal gland), there is concern that excess fluoride exposure may contribute to kidney disease - thus initiating a "vicious cycle" where the damaged kidneys increase the accumulation of fluoride, causing
Fluoride & Kidney Stones
It has long been suspected that fluoride may contribute to the formation of kidney stones. This suspicion has recently gained support from a study of an American man with skeletal fluorosis. According to the authors: "A new, important, medical problem (that seemed temporally related to cessation of fluoride exposure and subsequent negative calcium
Kidney: A potential target for fluoride toxicity
The kidneys are the organ responsible for clearing fluoride from the body. In the process of doing so, the kidneys are exposed to concentrations of fluoride that exceed, by a factor of 50, the concentration of fluoride in human blood. As such, the kidney have long been considered a potential
Fluoride as a Cause of Kidney Disease in Animals
Because the kidney is exposed to higher concentrations of fluoride than all other soft tissues (with the exception of the pineal gland), there is concern that excess fluoride exposure may contribute to kidney disease - thus initiating a "vicious cycle" where the damaged kidneys increase the accumulation of fluoride, causing in
Related FAN Content :