An investigation has been carried out on the effects of the intake of small amounts of sodium fluoride on kidney structure and function in rats, with a view to the possibility of establishing some means of testing for the toxic effects of fluorine in human beings, and of demonstrating the existence of a fluorine hazard before such severe intoxication has resulted as to cause disability and obvious skeletal lesions. The effects on kidney function are immediate.
Rats given small amounts of NaF in the diet exhibited, in addition to the well-known skeletal and dental lesions, marked polydipsia and polyuria,
… At autopsy the kidneys were dark, shrunken and nodulated.
Demonstration of alkaline phosphatase showed that there were fibrotic lesions in the cortex, where the enzyme was practically absent owing to absence of functional tubular tissue.
The histological examination indicated that in the kidneys there was a vascular, glomerular and more obviously tubular degeneration leading finally to interstitial fibrosis.
The fluoride-fed rats showed diminished growth, and at low body weights there was a marked diminution of fat stores.
Nitrogen metabolism was greater in the fluoride-fed rats than in the controls.
The effect of fluoride on the structure, function, and proteome of a renal epithelial cell monolayer
High concentrations of fluoride in the body may cause toxic effects. Here, we investigated the effects of fluoride on the structure, function, and proteome of a cortical collecting duct epithelium in vitro. Kidney tubule cells (M-1) were chosen because the concentration of fluoride in the kidney is 4-5-fold higher than
Evidence of selected nephrotoxic elements in Sri Lankan human autopsy bone samples of patients with CKDu and controls.
Background This article describes the analysis and interpretation of data relating to the presence of cadmium, lead, mercury and fluoride in human bone samples obtained from cadavers of patients dying of Chronic Kidney Disease of uncertain aetiology (CKDu) in a case-control study, which the authors believe to be the first in
[Changes of syndecan-4 and nuclear factor kB in the kidney of rat with chronic fluorosis].
Objective Aim of the study is to investigate the expression of syndecan-4 and nuclear factor kB (NF-kB) in the kidney of rat with chronic fluorosis,and to reveal the mechanism of kidney damage resulted from the toxicity of excessive amount of fluoride. Methods According to body mass and sex,sixty SD rats were
Fluoride osteosclerosis from drinking water
1. A case of osteosclerosis, exhibiting in addition mottled enamel, severe anemia showing no response to anti-anemic therapy, and bilateral renal lesions is reported. 2. The diagnosis of fluoride osteosclerosis was proved by the history of a long residence in areas of endemic fluorosis and by fluorine analysis of the patient's
Fluorosis caused cellular apoptosis and oxidative stress of rat kidneys
As the strongest electronegative element, fluorine can stimulate the production of superoxide radicals in cells. In view of the important roles of kidneys in bone metabolism, the authors analyzed the quantitative pathomorphological characteristics of renal damage and the potential cellular apoptosis and oxidative stress mechanisms in rats treated with excessive
Related Studies :
Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence
A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.
Fluoride as a Cause of Kidney Disease in Animals
Because the kidney is exposed to higher concentrations of fluoride than all other soft tissues (with the exception of the pineal gland), there is concern that excess fluoride exposure may contribute to kidney disease - thus initiating a "vicious cycle" where the damaged kidneys increase the accumulation of fluoride, causing in
Fluoride as a Cause of Kidney Disease in Humans
Because the kidney is exposed to higher concentrations of fluoride than all other soft tissues (with the exception of the pineal gland), there is concern that excess fluoride exposure may contribute to kidney disease - thus initiating a "vicious cycle" where the damaged kidneys increase the accumulation of fluoride, causing
Fluoride Gels & Kidney Function
Scientists have found that the application of "Fluoride Gels" at the dental office causes very high spikes in the blood fluoride level. The high spikes in blood fluoride levels are a result of three factors: the high concentration of fluoride in the gel (= 12.3 mg of fluoride in each
Fluoride & Kidney Stones
It has long been suspected that fluoride may contribute to the formation of kidney stones. This suspicion has recently gained support from a study of an American man with skeletal fluorosis. According to the authors: "A new, important, medical problem (that seemed temporally related to cessation of fluoride exposure and subsequent negative calcium
Related FAN Content :