Abstract
Eighty two children, aged 8 – 13 years old, from Wamiao village (severe endemic fluorosis area), from Xinhuai village (nonendemic fluorosis area) were 88 (as a control group), were recruited in this study. The prevalence of dental fluorosis (DF) were 85.37% (Wamiao) and 6.82% (Xinhuai) in two village’s children respectively; drinking water fluoride (F-) in children’s household shallow well from 0.62 – 4.00 mg/L in Wamiao and 0.23 – 0.76 mg/L in Xinhuai; serum total triiodothyronine (TT3), total thyronine (TT4), thyroid-stimulating hormone (TSH) were 1.47 ± 0.28 and 1.47 ± 0.33 ng/mL, 9.67 ± 1.76 and 9.22 ± 2.54 mg/dL, 3.88 ± 2.15 and 2.54 ± 2.07 mIU/mL in two villages children respectively. The prevalence of DF, drinking water F-, serum TSH in Wamiao village was significantly higher than that in Xinhuai village. As the children in Wamiao village were divided into different subgroups according to their severity of DF, serum TT3 and TSH showed significant difference in different groups. The results in this study confirmed that the high F- exposure can caused functional abnormalities of thyroid, and the different severity degree of DF may be relation to significant deviation in the serum levels of thyroid hormone.
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Effects of high fluoride and low iodine on thyroid function in offspring rats
Thirty-two Wistar rats were divided randomly into four groups of eight with six females and two males in each group. The rats were exposed to high fluoride drinking water (45 mg F- L-1 from 100 mg NaF L-1), low dietary iodine (0.0855 mg kg-1), or both together in order to
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Thyroid function, intelligence, and low-moderate fluoride exposure among Chinese school-age children.
Highlights Low-moderate fluoride was related to alterations in childhood thyroid function. Fluoride exposure was associated with a decrease in children’s intelligence. TT3, FT3 were positively related to the odds of developing high normal intelligence. TSH may modify the association of fluoride with children’s intelligence. Background: Thyroid hormones (THs) are critical for
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Fluoride-induced developmental disorders and iodine deficiency disorders as examples of developmental disorders due to disturbed thyroid hormone metabolism.
Both exposure to fluoride and iodine deficiency during early development can lead to disturbed thyroid hormone metabolism and produce the same spectrum of developmental disorders including short stature, bone deformities, cognitive impairment, delayed dental eruption, and dental fluorosis. The levels of creatinine-adjusted urinary fluoride experienced by pregnant women in areas
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Taurine ameliorates renal oxidative damage and thyroid dysfunction in rats chronically exposed to fluoride
Excessive exposure to fluoride poses several detrimental effects to human health particularly the kidney which is a major organ involved in its elimination from the body. The influence of taurine on fluoride-induced renal toxicity was investigated in a co-exposure paradigm for 45 days using five groups of eight rats each. Group I rats received
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[Effect of different fluoride and iodine concentration in drinking water on children's dental fluorosis and thyroid function].
Objective: To investigate the effect of different concentrations of fluoride and iodine in drinking water on children's dental fluorosis and thyroid function. Methods: According to different concentration of fluoride and iodine in drinking water, four villages in two counties of Henan province were classified as high fluoride and iodine, high fluoride,
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Fluoride's Impact on Thyroid Hormones
Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as
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Mikhailets (1996): Functional state of thyroid under extended exposure to fluorides
Abnormalities in the thyroid function characterized by a decreased iodine absorption function of the thyroid, a low level T3 syndrome, and a slight increase of the TSH level are observed in cases of chronic fluorine intoxication in the industrial workers.
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Fluoride & Goiter
Goitre (aka goiter) is an enlargement of the thyroid gland that in some cases can produce visible swelling in the neck. The main cause of goitre is iodine deficiency. Goitre can also be caused by other things, including hypothyroidism and substances that cause goitre (goitrogens). Since as far back as the
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Fluoride Aggravates Thyroid Damage Caused by Excess Iodine Intake
Chinese researchers have found that the combination of excess fluoride with excess iodine caused greater reductions in IQ, or greater increases in goitre than either scenario by itself.
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The Relationship Between Fluoride Exposure & Goitre in South Africa
As a general rule simple goitre, irrespective of the cause, can be very, or fairly, satisfactorily combated by an adequate increase in man's daily iodine intake, except when the enlargement of the gland is due to the ingestion of excessive amounts of fluorine. The only correct solution to fluorine-induced endemic goitre is the removal of this element from the drinking water.
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