Abstract
Eighty two children, aged 8 – 13 years old, from Wamiao village (severe endemic fluorosis area), from Xinhuai village (nonendemic fluorosis area) were 88 (as a control group), were recruited in this study. The prevalence of dental fluorosis (DF) were 85.37% (Wamiao) and 6.82% (Xinhuai) in two village’s children respectively; drinking water fluoride (F-) in children’s household shallow well from 0.62 – 4.00 mg/L in Wamiao and 0.23 – 0.76 mg/L in Xinhuai; serum total triiodothyronine (TT3), total thyronine (TT4), thyroid-stimulating hormone (TSH) were 1.47 ± 0.28 and 1.47 ± 0.33 ng/mL, 9.67 ± 1.76 and 9.22 ± 2.54 mg/dL, 3.88 ± 2.15 and 2.54 ± 2.07 mIU/mL in two villages children respectively. The prevalence of DF, drinking water F-, serum TSH in Wamiao village was significantly higher than that in Xinhuai village. As the children in Wamiao village were divided into different subgroups according to their severity of DF, serum TT3 and TSH showed significant difference in different groups. The results in this study confirmed that the high F- exposure can caused functional abnormalities of thyroid, and the different severity degree of DF may be relation to significant deviation in the serum levels of thyroid hormone.
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Effects of chronic fluorosis on thyroxine, triiodothyronine, and protein-bound iodine in cows
This study was conducted to evaluate the effects of chronic fluorosis in cows on their blood serum levels of thyroxine (T4), triiodothyronine (T3), and protein-bound iodine (PBI). Data collected from twenty cows with chronic fluorosis in the Tendurek Mountain region (altitude about 2000 m) in East Anatolia, Turkey, were compared
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Association of maternal urinary fluoride concentrations during pregnancy with size at birth and the potential mediation effect by maternal thyroid hormones: The Swedish NICE birth cohort.
Highlights Gestational fluoride exposure was associated with increased infant size at birth. Fluoride exposure was linked with increased odds of large for gestational age. Maternal thyroid hormone levels did not explain the observed associations. Background Observational studies have indicated that elevated maternal fluoride exposure during pregnancy may impair child neurodevelopment but
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Measurement of the content of T3, T4, and TSH in children in endemic fluorosis areas
The contents of T3, T4, TSH, urine fluoride, and urine iodine in 8-12 year-old children [were measured] in endemic fluorosis areas (water fluoride 3.52 mg/L). The results are: T4 content significantly decreased in the blood. T3 and TSH content was significantly elevated, and there is a positive correlation between the
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Effects of fluorosis on QT dispersion, heart rate variability and echocardiographic parameters in children - Original Investigation
OBJECTIVE: Chronic fluoride poisoning is called fluorosis. The aim of the study was to investigate effects of fluorosis on cardiovascular system in children by measuring QT dispersion (QTd), corrected QT dispersion (QTcd), heart rate variability (HRV) and echocardiography findings. METHODS: Thirty-five children with dental fluorosis and 26 children as control group
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A trial for improving thyroid gland dysfunction in rats by using a marine organism extract.
Understanding the relation between the environmental stress factors and the hypothalamus-pituitary-thyroid (HPT) axis efficiency can reduce the susceptibility to thyroid diseases. In our study, thyroid dysfunction was induced in female rats by administration of 40 mg Na F/kg.bd.wt/day for a month. Co-administration of the water extract of Arca noae (300 mg/kg.
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Fluoride's Impact on Thyroid Hormones
Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as
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Fluoride & Goiter
Goitre (aka goiter) is an enlargement of the thyroid gland that in some cases can produce visible swelling in the neck. The main cause of goitre is iodine deficiency. Goitre can also be caused by other things, including hypothyroidism and substances that cause goitre (goitrogens). Since as far back as the
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Is fluoride-induced hyperthyroidism a cause of psychosis among East African immigrants to Scandinavia?
When people with a compensated fluoride-induced hypothyroidism move to a low-fluoride area, the fluoride-induced inhibition of the production of thyroid hormones ceases. In Scandinavia, the dietary intake of iodine is usually quite high due to iodized table salt and easy access to marine fish. Under these conditions, the elevated capacity for production of thyroid hormones may result in hyperthyroidism.
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Fluorine in the Aetiology of Endemic Goitre
The distribution of endemic goitre in the Punjab and in England is related to the geological distribution of fluorine and to the distribution of human dental fluorosis (mottled enamel). Inquiry showed the presence of dental fluorosis among school-children in two areas of Somerset where two previous observers had recorded a high incidence of goitre, and the absence of dental fluorosis in an adjoining area selected as control where endemic goitre was absent.
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Fluoride Exposure Aggravates the Impact of Iodine Deficiency
A consistent body of animal and human research shows that fluoride exposure worsens the impact of an iodine deficiency. Iodine is the basic building block of the T3 and T4 hormones and thus an adequate iodine intake is essential for the proper functioning of the thyroid gland. When iodine intake is inadequate during infancy and
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