Abstract
Thyroid and immune statuses were studied in workers continuously exposed to fluorine. The examinees with euthyroid condition had immune disorders with an allergic tendency (increased number of B-lymphocytes, immunoglobulins A). In workers with subclinical hypothyrosis (tri-iodothyronine reduced in 51%), the immune alterations were more evident, T-lymphocytes count rose, but their functional activity declined, indicating impaired cooperation of immunocytes as a result of imperfect control under low concentrations of tri-iodothyronine.
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Fluoride in Drinking Water: A Scientific Review of EPA’s Standards.
Excerpts: Summary Under the Safe Drinking Water Act, the U.S. Environmental Protection Agency (EPA) is required to establish exposure standards for contaminants in public drinking-water systems that might cause any adverse effects on human health. These standards include the maximum contaminant level goal (MCLG), the maximum contaminant level (MCL), and the secondary
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Review of the Bartlett-Cameron survey: a ten year fluoride study.
Analysis of the data produced the following conclusions: 1. As was expected, dental fluorosis was significantly greater in Bartlett than in Cameron (all of the participants born and in continuous residence in Bartlett during the tooth formative period exhibited positive evidence of dental fluorosis). 2. The incidence of cardiovascular disease was higher
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Hypothyroidism and anemia related to fluoride in dairy cattle
Blood and urine were collected from 72 cows in six dairy herds with varying severity of dental and bone fluorotic lesions. Urinary fluoride averaged 5.13 ppm and ranged from 1.04 to 15.7 ppm fluoride. Thyroxine and triiodothyronine in serum decreased with increasing urinary fluoride, eosinophils increased, and cholesterol tended to
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Fluoride hypersensitivity in Mains tap water demonstrated by skin potential changes in guinea-pigs
Changes in skin electric potential following immune challenge provide a sensitive measure of the intensity of the allergic challenge. In guinea-pigs sensitised to Sodium Fluoride, Fluoridation Mains Tap Water, or Ovalbumen with Sodium Fluoride, and then challenged with one part in one million Sodium Fluoride, significant allergic responses were produced.
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Incidence of simple goiter in areas of endemic fluorosis in Nalgonda District, Andra Pradesh, India
The results of analyses of the mineral content of drinking water from three Indian villages with endemic fluorosis surveyed for the incidence of thyroid enlargement are reported. With the possible exception of temporary thyroid enlargement encountered in pubertal subjects (type b), no relation was found between the incidence of endemic goiter
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Is fluoride-induced hyperthyroidism a cause of psychosis among East African immigrants to Scandinavia?
When people with a compensated fluoride-induced hypothyroidism move to a low-fluoride area, the fluoride-induced inhibition of the production of thyroid hormones ceases. In Scandinavia, the dietary intake of iodine is usually quite high due to iodized table salt and easy access to marine fish. Under these conditions, the elevated capacity for production of thyroid hormones may result in hyperthyroidism.
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Fluoride's Impact on Thyroid Hormones
Up through the 1950s, doctors in Europe and South America prescribed fluoride for this purpose in patients with hyperthyroidism. (Merck Index 1968). Fluoride was selected as a thyroid suppressant based on findings dating back to the mid-19th century that fluoride is a goitrogen (a substance that can cause goiter). When used as
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Mikhailets (1996): Functional state of thyroid under extended exposure to fluorides
Abnormalities in the thyroid function characterized by a decreased iodine absorption function of the thyroid, a low level T3 syndrome, and a slight increase of the TSH level are observed in cases of chronic fluorine intoxication in the industrial workers.
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Fluoride & Goiter
Goitre (aka goiter) is an enlargement of the thyroid gland that in some cases can produce visible swelling in the neck. The main cause of goitre is iodine deficiency. Goitre can also be caused by other things, including hypothyroidism and substances that cause goitre (goitrogens). Since as far back as the
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Fluoride, Water Hardness, and Endemic Goitre
Variations in goitre prevalence were found to correlate closely with the fluoride content (p=0-74; P<0-01) and with the hardness (p=0.77; P<0-01) of the water in each village. The effects of fluoride and water hardness seem to be independent.
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