Abstract
The use of fluoridated products has significantly contributed to the reduction in rates of dental caries. However, excessive sodium fluoride (NaF) intake promotes inhibition of glycolysis, decrease in insulin secretion, hyperglycemia, and insulin resistance. Seven-week-old castrated male Wistar rats were used to evaluate the chronic effect of NaF on insulin sensitivity, insulin signal transduction in white adipose tissue (WAT), and plasma TNF-a and resistin concentrations. The animals were randomly divided into two groups: (1) control group (CN); (2) fluoride (F) group, which was treated with NaF in the drinking water and F in the food pellets (estimated total F intake: 4.0 mg/kg bw/day). After 42 days, an intravenous insulin tolerance test (0.75 U/kg), plasma TNF-a and resistin quantification analysis, and insulin receptor substrate (pp185 – IRS-1/IRS-2) tyrosine phosphorylation and IRS-1 serine phosphorylation status tests in WAT were performed. The chronic treatment with F promoted: (1) decrease in pp185 (IRS-1/IRS-2) tyrosine phosphorylation status in the WAT; (2) increase in IRS-1 serine phosphorylation status in the WAT; (3) increase in plasma concentrations of TNF-a and resistin; and (4) decrease in insulin sensitivity.
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Absence of detrimental effects of fluoride exposure in diabetic rats.
This study is part of a comprehensive programme to investigate fluoride toxicity and the hypothesis that fluoride ingested by "medically compromised' animals will result in altered physiological function. Its objectives were to monitor fluoride retention, tissue fluoride concentrations and genetic variables in diabetic and control rats chronically exposed to fluoride,
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Some current aspects of environmental fluoride
This review presents a Total Environment evaluation of current inorganic fluoride intake by human populations. Inorganicfluoride is a persistant bioaccumulator, and the ever-increasing use (and release) of fluoride compounds in the environment should be of long-term concern in population sub-groups who are most susceptible, and therefore, most "at risk". One of these sub-groups consists of
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Fluoride in Drinking Water: A Scientific Review of EPA’s Standards.
Excerpts: Summary Under the Safe Drinking Water Act, the U.S. Environmental Protection Agency (EPA) is required to establish exposure standards for contaminants in public drinking-water systems that might cause any adverse effects on human health. These standards include the maximum contaminant level goal (MCLG), the maximum contaminant level (MCL), and the secondary
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Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride
With half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated total F intake: 4.0 mg F/kg bw/day). After 42 days, determinations were made of the
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Influence of fluoride on streptozotocin induced diabetic nephrotoxicity in mice: protective role of Asian ginseng (Panax ginseng) & banaba (Lagerstroemia speciosa) on mitochondrial oxidative stress.
BACKGROUND & OBJECTIVES: Chronic fluoride intoxication through drinking water is a serious health problem. Patients with diabetes are known to have impaired renal function and elimination of fluoride from the body is mainly done through kidney. Fluoride toxicity in diabetes patients may aggravate complications. In this study, the influence of
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Fluoride & Impaired Glucose Tolerance
The proper regulation of blood glucose levels is essential to good health. When the body's ability to regulate blood glucose levels falters, as occurs in diabetes mellitus, chronic elevated glucose levels (hyperglycemia) can lead to serious complications. These consequences include damage to the kidneys, nervous system, cardiovascular system, retina, legs
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Fluoride Sensitivity Among Diabetics
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism “The present study showed that aortae and mesenteric arteries from streptozotocin-induced diabetic rats exhibited greater contractions
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Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism Excessive exposure to fluoride causes a defect of the tooth enamel known as dental fluorosis. In
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Fluoride & Insulin
Insulin is a hormone produced by the pancreas that is responsible for maintaining appropriate levels of glucose in the blood. Insulin allows the body’s cells to take up glucose from the blood, and either use it as an energy source or store it as glycogen. Blood glucose levels in diabetics
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NRC (2006): Fluoride's Effect on Glucose Metabolism
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism The following discussion is from pages 258-260 of the NRC’s report’s “Fluoride in Drinking Water: A Scientific
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