Abstract

Rats given sodium fluoride at 10 mg/kg daily by the intraperitoneal route were more sensitive to the convulsant action of strychnine and pentylenetetrazol and to electroshock. This increase in sensitivity to CNS stimulation was observed also in two other groups of rats which were given a diet with added sodium fluoride amounting to 7 and 70 parts per million in terms of fluoride. Prolonged treatment with fluoride also lengthened the sleeping time induced by pentobarbital and increased the protective effect of diphenylhydantoin against electroshock. The increase in sensitivity to some CNS-active agents in the fluoride-treated rats disappeared after these rats were given the control diet for 2 weeks,

• Related Studies :

  • The effect of small quantities of fluorine on the human body

    Clinical and physiological observations were made of school children in an endemic [area] where the fluorine content of water was within 1.6 mg/l. Stomatological examinations show that the prolonged use of drinking water containing these concentrations of fluorine causes among the children lesions of dental enamel of the I and

  • Chronic aluminum fluoride administration. I. Behavioral observations

    This study examined the behavioral effects of chronic ingestion of various monofluoroaluminum complexes (AlF3) in drinking water. Forty young adult male Long-Evans rats were divided into four groups of 10 rats each. The groups received different concentrations of AlF3 in the drinking water from three sample solutions having a total

  • Research on the neurobehavioural function of workers occupationally exposed to fluoride.

    Sixty-five operations workers (all males) in an electrolytic aluminum production facility were divided into two groups. The first group of 37 was employed for more than 5 years, and the second group of 28 for 5 years or less. These men had no history of liver, kidney, or immune-related disease. X-ray tests indicated that they were not suffering

  • Neurobehavioral toxicity produced by sodium fluoride in drinking water of laboratory rats

    The effect of exposure to different concentrations of sodium fluoride (Na-F) for different durations on learning and memory tasks in rats (non-associative and associative learning) was assessed in our study. Three groups of fifteen pregnant Wistar female rats each, were administered Na-F in drinking water at one of three concentrations;

  • Subchronic neurotoxicity in rats of the structural fumigant, sulfuryl fluoride

    Inhalation exposure of male and female Fischer 344 rats to sulfuryl fluoride [Vikane (Dow Chemical Company) gas fumigant] at 300 ppm for 6 hr/day, 5 days week, for 13 weeks caused diminished weight gain, dental fluorosis, a slight decrease in grooming, decreased flicker fusion threshold, slowing of flash, auditory and

• Related FAN Content :

  • NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects

    The NRC's analysis on fluoride and the brain.

  • Fluoride's Effect on Fetal Brain

    The human placenta does not prevent the passage of fluoride from a pregnant mother's bloodstream to the fetus. As a result, a fetus can be harmed by fluoride ingested pregnancy. Based on research from China, the fetal brain is one of the organs susceptible to fluoride poisoning. As highlighted by the excerpts

  • Fluoride Affects Learning & Memory in Animals

    An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out

  • Fluoride: Developmental Neurotoxicity.

    Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching

  • Fluoride's Direct Effects on Brain: Animal Studies

    The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.