Abstract

Thirty-two Wistar rats were divided randomly into four groups of eight rats each (female:male = 3:1). With one untreated group as a control group, the other three groups were administered, respectively, high fluoride in their drinking water (100 mg F/L from NaF), low iodine in their chow (0.0855 mg/kg), or both the high fluoride and low iodine together, in order to assess the effects of the three treatments on oxidative stress in the brain of offspring rats. After the animal model was established, the rats were allowed to breed, and 36 offspring rats in each group (female:male = 1:1) were randomly selected for the experiment. These rats were given the same treatment for the next 90 days as their parents. Superoxide dismutase (SOD) activity and the malondialdehyde (MDA) content in the brain of the combined high fluoride and low iodine group were significantly higher during and at the end of the 90-day period than in the control group, but the SOD/MDA ratio in this high fluoride and low iodine group was consistently lower than in the control group. These results suggest that brain stress from high fluoride and low iodine is one of the causes of reduction in learning and memory in offspring rats.

• Related Studies :

  • Relationship between intracellular Ca²+ and ROS during fluoride-induced injury in SH-SY5Y cells.

    The mechanisms underlying the neurotoxicology of endemic fluorosis still remain obscure. To explore lactate dehydrogenase (LDH) leakage, intracellular Ca²? concentration ([Ca²?]i ) and reactive oxygen species (ROS) production induced by fluoride, human neuroblastoma (SH-SY5Y) cells were incubated with sodium fluoride (NaF, 20, 40, 80 mg/L) for 24 h, with 40

  • Silymarin and quercetin abrogates fluoride induced oxidative stress and toxic effects in rats

    Flavonoids have been extensively studied and reported to possess widespread biological activities, including antioxidant and chelating properties. They have been proposed to exert beneficial effects in a multitude of diseased states generated due to oxidative stress. Therapeutic efficacy of oral administration of Silymarin and Quercetin after fluoride exposure (50 ppm

  • Pre and post natal exposure of fluoride induced oxidative macromolecular alterations in developing central nervous system of rat and amelioration by antioxidants.

    The effect of fluoride exposure during gestation and post gestation periods were studied to check the status of oxidant, antioxidant and macromolecular changes in CNS and ameliorative role of antioxidants. The pregnant Wistar albino rats were exposed to 50 and 150 ppm fluoride in drinking water and the pups born

  • Calcium preventing locomotor behavioral and dental toxicities of fluoride by decreasing serum fluoride level in rats

    Spontaneous motor activity, rota-rod performance (motor co-ordination), body weight gain, food intake, activities of total cholinesterase (blood) and acetylcholinesterase (brain), and dental structure were determined in adult female rats treated with a very high dose of sodium fluoride (500 ppm in drinking water) alone and in combination with calcium carbonate

  • Neuroprotective effect of ascorbic acid and ginkgo biloba against fluoride caused neurotoxicity

    Excessive consumption of fluoride through drinking water or other sources lead to skeletal and dental fluorosis. According to the world health organization 23 nations are facing the problem of fluorosis. In the recent past researchers describe the non-skeletal fluorosis where soft tissues and major organs are the victims of fluoride

• Related FAN Content :

  • Fluoride & Oxidative Stress

    A vast body of research demonstrates that fluoride exposure increases oxidative stress. Based on this research, it is believed that fluoride-induced oxidative stress is a key mechanism underlying the various toxic effects associated with fluoride exposure. It is also well established that fluoride's toxic effects can be ameliorated by exposure

  • Nutrient Deficiencies Enhance Fluoride Toxicity

    It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,

  • Fluoride Exposure Increases Metabolic Requirement for Magnesium

    Fluoride's toxicity is significantly enhanced in the presence of nutritional deficiencies. Similarly, fluoride exposure increases the body's requirement for certain nutrients. An individual with a high intake of fluoride, for example, will need a proportional increase in calcium to avoid the mineralization defects (e.g., osteomalacia) that fluoride causes to bone

  • Fluoride content in tea and its relationship with tea quality.

    J Agric Food Chem. 2004 Jul 14;52(14):4472-6. Fluoride content in tea and its relationship with tea quality. Lu Y, Guo WF, Yang XQ. Department of Tea Science, Zhejiang University, 268 Kaixuan Road, Hangzhou 310027, People's Republic of China. Abstract: The tea plant is known as a fluorine accumulator. Fluoride (F) content in fresh leaves collected

  • NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects

    The NRC's analysis on fluoride and the brain.