Abstract

Two experiments were conducted in order to determine if challenge testing, a procedure developed by clinical allergists, could be used to provoke behavioral reactions to chemicals found in municipal waters. In one experiment, 10 male and 32 female volunteers tracked a moving target and monitored lights after
receiving sublingual drops that contained only water or varying amounts of sodium fluoride and nitrate. Dosage levels in this experiment equaled, exceeded, or fell below those found in municipal waters. In a second experiment, 20 females performed this task after receiving sublingual drops of the same test substances in a repeated measures design; dosage levels equaled or exceeded levels found in municipal waters by 100 or 500 times, Neither type nor amount of chemical affected primary task performance; however, after receiving sublingual drops in the first (between-subjects) experiment, subjects paid less attention to lights on their right. In the second experiment, subjects made more errors and had longer
response latencies after they received moderate and very high concentrations of the test substances. It was concluded that challenge testing is a safe but effective technique for provoking and studying reactions to chemicals when it is combined with a sensitive measure of sensorimotor performance.

• Related Studies :

  • Subchronic neurotoxicity in rats of the structural fumigant, sulfuryl fluoride

    Inhalation exposure of male and female Fischer 344 rats to sulfuryl fluoride [Vikane (Dow Chemical Company) gas fumigant] at 300 ppm for 6 hr/day, 5 days week, for 13 weeks caused diminished weight gain, dental fluorosis, a slight decrease in grooming, decreased flicker fusion threshold, slowing of flash, auditory and

  • Chronic aluminum fluoride administration. I. Behavioral observations

    This study examined the behavioral effects of chronic ingestion of various monofluoroaluminum complexes (AlF3) in drinking water. Forty young adult male Long-Evans rats were divided into four groups of 10 rats each. The groups received different concentrations of AlF3 in the drinking water from three sample solutions having a total

  • Water treatment with silicofluorides and lead toxicity

    Toxic metals like lead, manganese, copper and cadmium damage neurons and deregulate neurotransmitters like serotonin and dopamine (which are essential to normal impulse control and learning). Earlier studies show that - controlling for socio-economic and demographic factors - environmental pollution with lead is a highly significant risk factor in predicting

  • Protective effects of aqueous extract of fruit pulp of Tamarindus indica on motor activity and metabolism of the gastrocnemius muscle of rats treated with fluoride

    This study reports the protective effects of tamarind ingestion against fluoride induced changes on motor activity and metabolism of Gastrocnemius muscle (GM) of rats. The male Wistar rats were divided into four groups - control, fluoride treated i.p. (20 mg NaF/Kg bw) and Tamarind (Tamarindus indicus III -150mg/kg bw and

  • Effect of fluoride exposure on anxiety- and depression-like behavior in mouse.

    Highlights Anxiety-like behavior was significantly altered in the mice exposed to NaF for 120 days. Depression-like behavior was significantly altered in the 120 days NaF treated mice. NaF significantly altered mRNA expression levels of anxiety- and depression-like related genes in the hippocampus. Fluoride led to an imbalance between excitation and

• Related FAN Content :

  • Fluoride's Direct Effects on Brain: Animal Studies

    The possibility that fluoride ingestion may impair intelligence and other indices of neurological function is supported by a vast body of animal research, including over 40 studies that have investigated fluoride's effects on brain quality in animals. As discussed by the National Research Council, the studies have consistently demonstrated that fluoride, at widely varying concentrations, is toxic to the brain.

  • Fluoride & IQ: 70 Studies

    As of June 2021, a total of 78 studies have investigated the relationship between fluoride and human intelligence. Of these investigations, 70 studies have found that elevated fluoride exposure is associated with reduced IQ in humans, while over 60 animal studies have found that fluoride exposure impairs the learning and/or

  • Fluoride: Developmental Neurotoxicity.

    Developmental Neurotoxicity There has been a tremendous amount of research done on the association of exposure to fluoride with developmental neurotoxicity. There are over 60 studies reporting reduced IQ in children and several on the impaired learning/memory in animals. And there are studies which link fluoride to Attention Deficit Hyperactivity Disorder. Teaching

  • Fluoride Affects Learning & Memory in Animals

    An association between elevated fluoride exposure and reduced intelligence has now been observed in 65 IQ studies. Although a link between fluoride and intelligence might initially seem surprising or random, it is actually consistent with a large body of animal research. This animal research includes the following 45 studies (out

  • NRC (2006): Fluoride's Neurotoxicity and Neurobehavioral Effects

    The NRC's analysis on fluoride and the brain.