Abstract

The author presents evidence of damage to the spinal cord in skeletal fluorosis. Since pressure on the cord by osteophytes was ruled out, direct action of fluoride on cord tissue is likely to be responsible for this condition.

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  • [Role of stanniocalcin 1 in brain injury of coal-burning-borne fluorosis rats].

    Objective: To observe the change of stanniocalcin 1 (STC1) and calcium content in brain of coal-burning-borne fluorosis rats, and to explore the role of STC1 in brain injury of coal-burning-borne fluorosis. Methods: Twenty four male SD rats were randomly divided into control, low, medium, and high fluoride groups according to body

  • The effect of fluorine on the developing human brain.

    Fifteen fetuses from an endemic fluorosis area that were aborted therapeutically at the 5th–8th month of gestation were compared with 16 aborted fetuses from a non-endemic area. Stereological study of the brains showed that the numerical density of the neuron volume and the undifferentiated neuroblasts as well as the nucleus-cytoplasm ratio of the neurons were

  • Apoptotic and Degenerative Changes in the Enteric Nervous System Following Exposure to Fluoride During Pre- And Post-natal Periods.

    Children born in fluorosis endemic areas usually suffer from gastrointestinal complications and are unable to attain normal growth as per their age group. The enteric nervous system (ENS) controls gut movement and functions. It is highly vulnerable to any ingested toxins. Based on observations, it was hypothesized that fluoride exposure

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    To assess brain cell apoptosis induced by high fluoride and/or low iodine in their offspring, 32 one-month old Wistar albino rats were divided randomly into four equal groups, each with six females and two males. The first group of rats served as the untreated controls; the second group received high

  • Proteomic analysis of brain proteins of rats exposed to high fluoride and low iodine.

    Epidemiological investigations reveal that high fluoride and low iodine have strong adverse effects on the intelligence quotient (IQ) of children. Studies also report that in some high fluoride areas, iodine deficiency also exists, especially in China. Here, with the proteomic techniques, we first report on the proteomic changes in brain

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