Fluoride Action Network


The hyperglycemia which accompanies acute fluoride toxicity in the rat is mediated by epinephrine released from the adrenal medulla. Bilateral splanchnicotomy prevented this response to fluoride. Ganglionic blockade diminished the hyperglycemic response in unanesthetized animals but not in pentobarbital-anesthetized animals. Microinjections of fluoride into the lateral ventricle elicited a rapid hyperglycemia in unanesthetized animals which again was blocked partially by ganglionic blockade. The response to fluoride appears to be mediated primarily by splanchnic impulses arising in the central nervous system.