Abstract
The oral administration of sodium fluoride (NaF) (40 mumol/100 body weight [bw]) to fasting rats produced an immediate fall in insulin levels and the consequent increase in glycemia. These phenomena were observed with plasma fluoride concentrations 5-15 microM. Glycemia and insulin returned to normal levels within 4-5 hours, together with the washing out of fluoride from plasma and soft tissues. The insulin secretion of isolated Langerhans islets, perifused with solutions containing 5, 10, or 20 microM fluoride, was found to be significantly inhibited as a function of fluoride levels, both with basal and stimulatory concentrations of glucose. One hour after the intake of 60 mg of NaF, fasting human volunteers showed increased fluoride (5-15 microM) together with a significant fall of plasma insulin levels.
Excerpt:
“The data reported in this paper indicate that the transient fluoride increase after an oral dose produces a transitory inhibition of insulin secretion with hyperglycemia as a consequence. . . . The phenomenon was also observed in human beings.”
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Fluoride-induced resistance to insulin in the rat.
The insulinic response of rats challenged with glucose at different times after an oral dose of 40 µmol NaF/100 g bw revealed the concentration of the molecular species reacting with anti-insulin antibody was significantly lower after 3 hr, and the glucose levels were somewhat higher than in controls. At the
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Comparative study of the effect of sodium fluoride and sodium monofluorophosphate on glucose homeostasis in the rat.
The effect of acute and chronic administration of sodium fluoride (NaF) or sodium monofluorophosphate (MFP) on the glucose homeostasis of the rat are compared. The oral administration of a single dose of 40 mumol/100 g b.w. of either compound produced similar increases in plasma glucose (up to 1.8 g/l) and
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Chronic fluorides impact on pancreatic islet cells in workers
Summary: Decreasing of the insulin concentration and increasing of the C-peptide level in blood serum of 72 workers of cryolytes industries detected by radioimmunilogical method. These changes were caused by the fluorine intoxication of workers.
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Effect of F on rat serum insulin levels in vivo
Several investigators have shown an acute administration of NaF in rats can induce a hyperglycemia. The current study was undertaken to determine if acute injections of NaF would alter the serum insulin levels since LIN et al., Horm. Metab. Res 8, 353-358, 1976 had shown that NaF could inhibit the
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Effect of fluoridated water on plasma insulin levels and glucose homeostasis in rats with renal deficiency.
Glucose intolerance in fluorosis areas and when fluoride is administered for the treatment of osteoporosis has been reported. Controlled fluoridation of drinking water is regarded as a safe and effective measure to control dental caries. However, the effect on glucose homeostasis was not studied so far. The aim of this
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Fluoride & Insulin
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Fluoride Sensitivity Among Diabetics
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Fluoride & Impaired Glucose Tolerance
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NRC (2006): Fluoride's Effect on Glucose Metabolism
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism The following discussion is from pages 258-260 of the NRC’s report’s “Fluoride in Drinking Water: A Scientific
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Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus
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