Abstract
Addition of NaF or MFP to rat hepatocytes resulted in a decrease in lactate and in an increase in glucose, 3 and 2-phosphoglycerate production. When dihydroxyacetone was present in the incubation medium both NaF and MFP increased the production of glucose, fructose-1,6-diphosphate, 3 and 2 phosphoglycerate, with a decrease in pyruvate and lactate. In the presence of lactate, glucose production increased only in the presence of MFP, but there was a 8–10 fold increase in the level of phosphoenol pyruvate with both NaF and MFP. The crossover data indicated that the activity of some of the glycolytic enzymes may be inhibited in the presence of NaF and MFP.
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Gluconeogenesis and glycogenolysis in fluoride-treated rats.
Intraperitonial administration of 10 mg fluoride (NaF)/kg body weight resulted in hyperglycemia in rats. Role of gluconeogenesis and glycogenolysis in this hyperglycemic response was evaluated. Results of the study indicate that the fluoride induced hyperglycemia is mainly due to increased hepatic glycogenolysis.
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Influence of extended exposure to sodium fluoride and caffeine on the activity of carbohydrate metabolism enzymes in rat blood serum and liver.
A 50-day study of the influence of fluoride (F) and caffeine on carbohydrate metabolism enzymes was conducted on 18 male Sprague-Dawley rats, 4.5 months old, housed in separate cages at 22–25°C on a 12-hr light/dark cycle. The rats were divided into three groups with six rats in each group: control,
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Ameliorative effect of tamarind leaf on fluoride-induced metabolic alterations
OBJECTIVES: Fluoride is a serious health hazard across several nations, and chronic intake of fluoride deranges the carbohydrate, lipid and antioxidant metabolism in general. As there are limited remedial measures to prevent fluorosis, we investigated the role of tamarind leaf as a food supplement in restoration of carbohydrate, lipid and
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Co-exposure to Arsenic-Fluoride Results in Endoplasmic Reticulum Stress-Induced Apoptosis Through the PERK Signaling Pathway in the Liver of Offspring Rats.
Arsenic and fluoride are two of the major groundwater pollutants. To better understand the liver damage induced during development, 24 male rats exposed to fluoride (F), arsenic (As), and their combination (As + F) from the prenatal stage to 90 days after birth were selected for analysis. Histopathological results showed
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Study on blood biochemical diagnostic indices for hepatic function biomarkers in endemic skeletal fluorosis
The aim of the study was to determine the relationship of fluoride in drinking water to liver function in individuals living in normal and seven endemic fluorosis areas of Punjab, India. The concentration of fluoride in drinking water of different areas varied from 5.9 to 24.5 mg/L. Study group consisted
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