Serum glucose was elevated immediately after ip administration of a single large dose of fluoride (NaF 35 mg/kg) to rats. Moreover, elevation of serum glucose following ip administration of 35 mg/kg of fluoride to rats was suppressed by adrenalectomy, dibenamine, or propranolol, but not by thyroid-parathyroidectomy. The elevation of serum glucose was associated with enhancement of glucose-6-phosphatase activities in liver and kidney in fluoride-treated rats.
Establishment of drug delivery system nanocapsulated with an antioxidant (+)-catechin hydrate and sodium meta borate chelator against sodium fluoride induced oxidative stress in rats
Oxidative stress a major cause of fluoride induced toxicity and mitochondrial impairment in common in experimental rats during chronic exposure of fluoride. Attempts have been made in the present experiment to diminish oxidative damage, combined therapy with (+)-catechin hydrate (an antioxidant) and sodium meta borate (chelator) were used. Fluoride intoxication
Effects of chronic fluoride intake on the antioxidant systems of the liver and kidney in rats
Excessive fluoride intake over a long period of time can lead to fluorosis, which may cause dental and skeletal manifestations. Metabolic, functional and structural damage caused by chronic fluorosis have been reported in many tissues, but the exact mechanisms modulated by fluoride remain unclear. The aim of this study was
Effect of Fluoride on the Expression of 8-Hydroxy-2'-Deoxyguanosine in the Blood, Kidney, Liver, and Brain of Rats.
Excessive exposure of fluoride not only leads to damage on bone, but also has an adverse effect on soft tissues. Oxidative DNA damage induced by fluoride is thought to be one of the toxic mechanisms of fluoride effect. However, the dose–response of fluoride on oxidative DNA damage is barely studied
Ameliorative effect of tamarind leaf on fluoride-induced metabolic alterations
OBJECTIVES: Fluoride is a serious health hazard across several nations, and chronic intake of fluoride deranges the carbohydrate, lipid and antioxidant metabolism in general. As there are limited remedial measures to prevent fluorosis, we investigated the role of tamarind leaf as a food supplement in restoration of carbohydrate, lipid and
Protective effects of vitamin C against fluoride toxicity.
Fluorine is a highly toxic substance that is widely distributed with drinking water and nutrients. While fluorine is not free in nature, it can form compounds with almost all metals and nonmetals except oxygen and inert gases. Fluorine is found in the environment in water, soil, air, nutrients, and vegetation
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