Abstract

Serum glucose level was elevated immediately after ip administration of a single large dose of fluoride (NaF 35 mg/kg) to rats. The elevation of serum glucose was markedly suppressed by adrenalectomy, dibenamine or propranolol, but not by thyroid-parathyroidectomy. Elevation of serum glucose was found to be associated with enhancement of glucose-6-phosphatase activities in the liver and kidney of fluoride-treated rats. On the other hand, renal calcium was elevated gradually as compared to the augment of serum glucose and cyclic AMP following the fluoride administration. The elevation of renal calcium was markedly suppressed by thryroid-parathyroidectomy.

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