Abstract

A chronic intake of fluoride through food and drinking water is also known to cause hyperglycemia and dyslipidemia besides fluorosis. The present study deals with the effects of fluoride (100 ppm) induced hyperglycemia and dyslipidemia and the alleviatory potential of Mangifera indica L. on the carbohydrate and lipid profiles in laboratory rats. Exposure to fluoride resulted in significant elevation in plasma glucose, hepatic glucose-6-phosphatase, plasma and hepatic lipid profiles and a reduction in plasma HDL-C, hepatic glycogen content and hexokinase activity. Inclusion of different doses of M. indica fruit powder (2.5, 5 and 10 gm%) in the basal diet brought about a dose- dependent reversal of diabetes like complications, i.e., a significant reduction in plasma glucose, increase in glycogenesis and decrease in glyconeogenesis in the treatment groups. All the three doses also decreased the hyperlipidemic status by reducing the plasma and hepatic total lipids, total cholesterol, triglycerides, plasma low & density lipoprotein cholesterol, very low-density lipoprotein cholesterol with a concurrent increase in high-density lipoprotein cholesterol contents. Therefore, it is concluded that M. indica fruit powder as a food supplement can reduce the fluoride induced hyperglycemia and hyperlipidemia.

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