Abstract
A chronic intake of fluoride through food and drinking water is also known to cause hyperglycemia and dyslipidemia besides fluorosis. The present study deals with the effects of fluoride (100 ppm) induced hyperglycemia and dyslipidemia and the alleviatory potential of Mangifera indica L. on the carbohydrate and lipid profiles in laboratory rats. Exposure to fluoride resulted in significant elevation in plasma glucose, hepatic glucose-6-phosphatase, plasma and hepatic lipid profiles and a reduction in plasma HDL-C, hepatic glycogen content and hexokinase activity. Inclusion of different doses of M. indica fruit powder (2.5, 5 and 10 gm%) in the basal diet brought about a dose- dependent reversal of diabetes like complications, i.e., a significant reduction in plasma glucose, increase in glycogenesis and decrease in glyconeogenesis in the treatment groups. All the three doses also decreased the hyperlipidemic status by reducing the plasma and hepatic total lipids, total cholesterol, triglycerides, plasma low & density lipoprotein cholesterol, very low-density lipoprotein cholesterol with a concurrent increase in high-density lipoprotein cholesterol contents. Therefore, it is concluded that M. indica fruit powder as a food supplement can reduce the fluoride induced hyperglycemia and hyperlipidemia.
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Topical fluorides: effects on physiologic and biochemical processes
The ingestion of fluoride from dentifrices or mouthrinses can contribute substantially to the total daily intake of the ion, even in communities that provide optimally fluoridated drinking water. It is concluded that the frequent and unsupervised use of these products by children six years of age or younger, especially those living in
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Reversible impairment of glucose tolerance in patients with endemic fluorosis. Fluoride Collaborative Study Group.
Endemic fluorosis is a condition resulting from prolonged ingestion of drinking water which contains excess fluoride. Studies on rats have suggested that fluoride toxicity may produce glucose intolerance and abnormalities in insulin secretion. We studied glucose and insulin profiles following an oral glucose load in patients with endemic fluorosis. Twenty-five
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Fundamental and applied studies on transport and metabolism of electrolytes and glucose--aim to contact with molecular biology. [Article in Japanese]
The authors' research focuses on polyuria, natriuresis, glucosuria, glycemia, and renal calcification in occupational lead poisoning and endemic fluorosis. Changes in electrolyte mobilization and in glucose metabolism and transport following the administration of lead compounds or fluoride were examined to elucidate these mechanisms. The results suggest fundamental approaches to the
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Fluoride-induced resistance to insulin in the rat.
The insulinic response of rats challenged with glucose at different times after an oral dose of 40 µmol NaF/100 g bw revealed the concentration of the molecular species reacting with anti-insulin antibody was significantly lower after 3 hr, and the glucose levels were somewhat higher than in controls. At the
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Correlation between serum fluoride and hyperglycemia in endemic fluorosis area
As fluoride inhibits Glycolysis we conducted a preliminary study to analyse the effect of fluoride on blood glucose in the individuals of endemic fluorosis area . The study was conducted to correlate the serum fluoride with blood glucose levels in a population living in endemic fluorosis area The present study included serum
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Fluoride & Insulin
Insulin is a hormone produced by the pancreas that is responsible for maintaining appropriate levels of glucose in the blood. Insulin allows the body’s cells to take up glucose from the blood, and either use it as an energy source or store it as glycogen. Blood glucose levels in diabetics
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NRC (2006): Fluoride's Effect on Glucose Metabolism
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism The following discussion is from pages 258-260 of the NRC’s report’s “Fluoride in Drinking Water: A Scientific
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Fluoride Sensitivity Among Diabetics
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism “The present study showed that aortae and mesenteric arteries from streptozotocin-induced diabetic rats exhibited greater contractions
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Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism Excessive exposure to fluoride causes a defect of the tooth enamel known as dental fluorosis. In
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Fluoride & Impaired Glucose Tolerance
The proper regulation of blood glucose levels is essential to good health. When the body's ability to regulate blood glucose levels falters, as occurs in diabetes mellitus, chronic elevated glucose levels (hyperglycemia) can lead to serious complications. These consequences include damage to the kidneys, nervous system, cardiovascular system, retina, legs
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