Abstract
A chronic intake of fluoride through food and drinking water is also known to cause hyperglycemia and dyslipidemia besides fluorosis. The present study deals with the effects of fluoride (100 ppm) induced hyperglycemia and dyslipidemia and the alleviatory potential of Mangifera indica L. on the carbohydrate and lipid profiles in laboratory rats. Exposure to fluoride resulted in significant elevation in plasma glucose, hepatic glucose-6-phosphatase, plasma and hepatic lipid profiles and a reduction in plasma HDL-C, hepatic glycogen content and hexokinase activity. Inclusion of different doses of M. indica fruit powder (2.5, 5 and 10 gm%) in the basal diet brought about a dose- dependent reversal of diabetes like complications, i.e., a significant reduction in plasma glucose, increase in glycogenesis and decrease in glyconeogenesis in the treatment groups. All the three doses also decreased the hyperlipidemic status by reducing the plasma and hepatic total lipids, total cholesterol, triglycerides, plasma low & density lipoprotein cholesterol, very low-density lipoprotein cholesterol with a concurrent increase in high-density lipoprotein cholesterol contents. Therefore, it is concluded that M. indica fruit powder as a food supplement can reduce the fluoride induced hyperglycemia and hyperlipidemia.
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Comparative study of the effect of sodium fluoride and sodium monofluorophosphate on glucose homeostasis in the rat.
The effect of acute and chronic administration of sodium fluoride (NaF) or sodium monofluorophosphate (MFP) on the glucose homeostasis of the rat are compared. The oral administration of a single dose of 40 mumol/100 g b.w. of either compound produced similar increases in plasma glucose (up to 1.8 g/l) and
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Vitamin D deficiency in patients with diabetes and its correlation with water fluoride levels.
Chronic exposure to fluoride through drinking water has been linked to insulin resistance and resulting type 2 diabetes mellitus (T2DM). Here, we aim to study the impact of water fluoride levels on blood glucose and vitamin D levels. A hospital-based study was conducted on diabetic patients (n = 303) at
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Physiologic and metabolic benefits of formulated diets and mangifera indica in fluoride toxicity
Fluorosis is a major health problem affecting normal physiological and metabolic functions in people living in endemic fluoride areas. The present work was aimed at investigating the role of basal, high carbohydrate low protein (HCLP) and high protein low carbohydrate (HPLC) diets and Mangifera indica fruit powder as a food
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Effect of fluoridated water on plasma insulin levels and glucose homeostasis in rats with renal deficiency.
Glucose intolerance in fluorosis areas and when fluoride is administered for the treatment of osteoporosis has been reported. Controlled fluoridation of drinking water is regarded as a safe and effective measure to control dental caries. However, the effect on glucose homeostasis was not studied so far. The aim of this
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Correlation between serum fluoride and hyperglycemia in endemic fluorosis area
As fluoride inhibits Glycolysis we conducted a preliminary study to analyse the effect of fluoride on blood glucose in the individuals of endemic fluorosis area . The study was conducted to correlate the serum fluoride with blood glucose levels in a population living in endemic fluorosis area The present study included serum
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Fluoride & Insulin
Insulin is a hormone produced by the pancreas that is responsible for maintaining appropriate levels of glucose in the blood. Insulin allows the body’s cells to take up glucose from the blood, and either use it as an energy source or store it as glycogen. Blood glucose levels in diabetics
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Fluoride & Impaired Glucose Tolerance
The proper regulation of blood glucose levels is essential to good health. When the body's ability to regulate blood glucose levels falters, as occurs in diabetes mellitus, chronic elevated glucose levels (hyperglycemia) can lead to serious complications. These consequences include damage to the kidneys, nervous system, cardiovascular system, retina, legs
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NRC (2006): Fluoride's Effect on Glucose Metabolism
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism The following discussion is from pages 258-260 of the NRC’s report’s “Fluoride in Drinking Water: A Scientific
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Fluoride Sensitivity Among Diabetics
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism “The present study showed that aortae and mesenteric arteries from streptozotocin-induced diabetic rats exhibited greater contractions
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Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism Excessive exposure to fluoride causes a defect of the tooth enamel known as dental fluorosis. In
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