Abstract
Peripheral blood lymphocytes of residents of three villages and one nearby township in South Gujarat with fluoride concentrations in the drinking water of 1.56 – 3.46 and 0.6 – 0.8 ppm, respectively, were examined for their frequency of sister chromatid exchanges (SCE) and chromosome aberra-tions. The rates of SCEs and chromosome aberrations in persons living in one of the endemic villages were significantly higher than in the others, and their lymphocytes were more susceptible to the clastogen Mitomycin-C.
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Fluoride does not induce DNA breakage in Chinese hamster ovary cells in vitro
Fluoride has been widely used in dentistry because it is a specific and effective caries prophylactic agent. However, excess fluoride may represent a hazard to human health, especially by causing injury to genetic material. Genotoxicity tests represent an important part of cancer research to assess the risk of potential carcinogens.
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Cytological effects of sodium fluoride on mice
Inbred mice, fed a low-fluoride diet, 0.263 + 028 ppm F, were given drinking water containing 0, 1, 5, 10, 50, 100, or 200 ppm F for 3 to 6 weeks. Cytological studies on bone marrow cell chromosomes and spermatocytes showed that 1-200 ppm F (as sodium fluoride) was able
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Sodium fluoride induced chromosome aberrations and sister chromatid exchange in cultured human lymphocytes
Experimental sodium fluoride (NaF) up 10 30 times the level recommended In drinking waler (1 ppm) was compared with an inorganic salt for its ability to induce chromosome aberrations and sister chromatid exchange (SCE) in cultured human lymphocytes. An increase in the frequencies of chromosome aberrations but not of SCE
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Sister-chromatid exchanges in lymphocytes of workers at a phosphate fertilizer factory
The frequencies of sister-chromatid exchange (SCE) in peripheral blood lymphocytes of 40 workers at a phosphate fertilizer factory in North China were studied. HF and SiF4 are main air pollutants in the factory, there is also some dust containing fluoride, phosphate fog, NH3 and SO2. It was shown that the
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[Modifying effect of nutrition on the mutagenic activity of phosphorus and fluorine compounds].
The test animals were fed with low-grade food during 2-5 months under conditions of acute and chronic action of hydrogen phosphide and hydrogen fluoride induced by inhalation, that resulted in the pronounced impairment of the chromosomal apparatus of the bone marrow cells in the rats. A principal possibility has been
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Fluoride & Liver Cancers in NTP Bioassay
On October 28, 1988, Battelle Columbus Laboratories submitted its Final Report to the NTP concerning the results of the Mouse study. The principal finding of Battelle's report was that a dose-dependent increase of a rare liver cancer (hepatocholangiocarcinoma) had occurred in the fluoride-treated male and female mice.
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Fluoride's Mutagenicity: The "Oral Health Research Institute's" Studies
Although many in vitro and in vivo studies have detected mutagenic effects from fluoride exposure, the Oral Health Research Institute at Indiana University's School of Dentistry has repeatedly failed to find any such effect in multiple studies on the subject.
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Micronucleus and Sister Chromatid Exchange Frequency in Endemic Fluorosis
The rise of sister chromatid exchange (SCE) and micronucleus (MN) in the peripheral blood lymphocytes of the fluorine-intoxicated patients indicates that fluorine is a mutagenic agent which can cause DNA and chromosomal damage.
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Fluoride's Mutagenicity: In vitro Studies
According to the National Toxicology Program, "the preponderance of evidence" from laboratory "in vitro" studies indicate that fluoride is a mutagenic compound. Many substances which are mutagens, are also carcinogens (i.e. they can cause cancer). As is typical for in vitro studies, the concentrations of fluoride that have generally been tested
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NTP Bioassay on Fluoride/Cancer (1990)
In 1977, the U.S. Congress requested that animal studies be conducted to determine if fluoride can cause cancer. The result of the Congressional request was an extensive animal study conducted in the 1980s by the National Toxicology Program (NTP) and published in 1990. The main finding of NTP's study was a dose-dependent increase in osteosarcoma (bone cancer) among the fluoride-treated male rats.
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