Abstract

Inbred mice, fed a low-fluoride diet, 0.263 + 028 ppm F, were given drinking water containing 0, 1, 5, 10, 50, 100, or 200 ppm F for 3 to 6 weeks. Cytological studies on bone marrow cell chromosomes and spermatocytes showed that 1-200 ppm F (as sodium fluoride) was able to induce chromosomal changes in a dose-dependent manner. The frequency of the induced chromosomal damage was significantly higher in each treatment than in the controls. The observed abnormalities included translocations, dicentrics, ring chromosomes, and bridges plus fragments, or fragments by themselves. There was a significant correlation between the amount of fluoride in the body ash and the frequency of the chromosomal abnormalities.

• Related Studies :

  • DNA damage induced by fluoride in rat osteoblasts

    A study is reported of DNA damage by fluoride to primary calvarial osteoblasts of newborn rats isolated by enzymic digestion. Sodium fluoride at concentrations of 0, 0.5, 1, 2, and 3 mmol/L was administered to the isolated osteoblast cells for 24 hr, and damage to DNA was determined by single

  • Induction of chromosomal aberrations in male mouse germ cells by uranyl fluoride containing enriched uranium

    Cytogenetic damage induced by a wide range of concentrations of uranyl fluoride injected into mouse testes was evaluated by determining the frequencies of chromosomal aberrations in spermatogonia and primary spermatocytes. Breaks, gaps and polyploids were observed in spermatogonia. The frequencies of the significant type of aberration, breaks, were induced according

  • Cytogenetic effects of hydrogen fluoride gas on maize

    Maize seedlings of the genotype C I Sh Wx were fumigated with hydrogen fluoride gas (HF) continuously for 4, 6, 8 and 10 days. Miscrospore mitosis of the treated plants indicated the presence of fragments and bridges suggesting the occurrence of the phenomenon of breakage-fusion-bridge cycle of McClintock. This phenomenon

  • Chromosomal changes in maize induced by hydrogen fluoride gas

    Maize seedlings of the genotype A1A2C1Wx were fumigated in growth chambers with hydrogen fluoride (HF) at a concentration of about 3 ug/m3. The experiment was run for 10 days, with the first group of treated plants removed from the chambers after 4 days and then at intervals of 2 days.

  • Effect of static magnetic field on the induction of micronuclei by some mutagens

    OBJECTIVES:  It is important to assess the risk of static magnetic fields (SMFs) on human health, because epidemiological studies have indicated that SMFs play a role in the development of diseases such as leukemia and brain tumor. In our environment, we have numerous chances to be exposed to not only

• Related FAN Content :

  • NTP Bioassay on Fluoride/Cancer (1990)

    In 1977, the U.S. Congress requested that animal studies be conducted to determine if fluoride can cause cancer. The result of the Congressional request was an extensive animal study conducted in the 1980s by the National Toxicology Program (NTP) and published in 1990. The main finding of NTP's study was a dose-dependent increase in osteosarcoma (bone cancer) among the fluoride-treated male rats. 

  • A Critique of Gelberg's Study on Fluoride/Osteosarcoma in New York

    The case-control study by Gelberg, published first as a PhD dissertation and then later in two peer-reviewed journals, may represent the most substantive study on fluoride/osteosarcoma previous to Bassin’s 2001 analysis. In assessing Gelberg’s data, we were at first struck by the existence of several notable errors in both the thesis and papers. While these errors do raise questions about the study, our primary concern with Gelberg’s work relates to the methods she used to analyze her data.

  • Fluoride's Mutagenicity: The "Oral Health Research Institute's" Studies

    Although many in vitro and in vivo studies have detected mutagenic effects from fluoride exposure, the Oral Health Research Institute at Indiana University's School of Dentistry has repeatedly failed to find any such effect in multiple studies on the subject.

  • Fluoride's Mutagenicity: In vivo Studies

    Consistent with dozens of in vitro studies, a number of in vivo studies, in both humans and animals, have found evidence of fluoride-induced genetic damage. In particular, research on humans exposed to high levels of fluoride have found increased levels of "sister chromatid exchange" (SCE). As noted in one study: "In

  • Fluoride's Mutagenicity: In vitro Studies

    According to the National Toxicology Program, "the preponderance of evidence" from laboratory "in vitro" studies indicate that fluoride is a mutagenic compound. Many substances which are mutagens, are also carcinogens (i.e. they can cause cancer). As is typical for in vitro studies, the concentrations of fluoride that have generally been tested