Abstract

The purpose of this preliminary investigation was to compare the genotoxic effect of fluoride in human individuals directly exposed to high concentrations of drinking water fluoride (1.95 to 2.2 ppm) with those in individuals exposed to concentrations (0.6 to 1.0 ppm) within the WHO permissible limit. Sister chromatid exchanges (SCE) and cell cycle proliferative index were studied in whole-blood cultures of fluorotic individuals and compared with normal controls of age-matched groups. The results suggest that the SCE rate in persons exposed to fluoride in the endemic (1.95-2.2 ppm) areas of North Gujurat is significantly higher than that of those living in Ahmedabad (0.6-1.0 ppm). There is no significant difference in cell cycle proliferative index. Further investigations are needed to confirm these findings.

• Related Studies :

  • Effect of sodium fluoride on tumor growth

    Recently a report (1) from this laboratory indicated that NaBr in relatively low concentrations accelerated the growth of mouse and egg cultivated tumor tissue. This result occurred when the drug was introduced by way of the drinking water in mice, by injection over the embryonic membranes of eggs inoculated with

  • Clastogenic activity of sodium fluoride in great ape cells

    Conflicting evidence has been reported concerning the mutagenicity of sodium fluoride (NaF), especially clastogenicity at concentrations of more than 1 mM. NaF is known to induce chromosome aberrations at these concentrations in human cells, but not in most rodent cells. We considered that such species-specific difference in chromosomal sensitivity would

  • Genotoxic effect of an environmental pollutant, sodium fluoride, in mammalian in vivo test system

    Genotoxicity of Sodium fluoride was evaluated in mice in vivo with the help of different cytogenetic assays. The frequency of chromosome aberration was dose - and time - dependent but not exactly route-dependent. Fractionated dosing induced less aberration. Incidence of micronucleus and sperm abnormality increased with dose. Relative sensitivity of

  • Chromosomal aberrations and sister-chromatid exchanges in Lithuanian populations: effects of occupational and environmental exposures

    Cytogenetic analysis of chromosomal aberrations (CA) in 175,229 cells from 1113 individuals, both unexposed and occupationally or environmentally exposed to heavy metals (mercury and lead), organic (styrene, formaldehyde, phenol and benzo(a)pyrene) and inorganic (sulfur and nitrogen oxides, hydrogen and ammonium fluorides) volatile substances and/or ionizing radiation was performed. In addition,

  • Genotoxic evaluation of sodium fluoride in the Somatic Mutation and Recombination Test (SMART)

    In this study, genotoxic effect of sodium fluoride (NaF) was investigated in Drosophila melanogaster Somatic Mutation and Recombination Test. Third-instar larvae trans-heterozygous for two genetic markers mwh and flr, were treated at different concentrations (2.5 microg/ml, 5 microg/ml and 10 microg/ml) of the test compounds. After the treatment the observed

• Related FAN Content :

  • Fluoride's Mutagenicity: The "Oral Health Research Institute's" Studies

    Although many in vitro and in vivo studies have detected mutagenic effects from fluoride exposure, the Oral Health Research Institute at Indiana University's School of Dentistry has repeatedly failed to find any such effect in multiple studies on the subject.

  • Fluoride's Mutagenicity: In vitro Studies

    According to the National Toxicology Program, "the preponderance of evidence" from laboratory "in vitro" studies indicate that fluoride is a mutagenic compound. Many substances which are mutagens, are also carcinogens (i.e. they can cause cancer). As is typical for in vitro studies, the concentrations of fluoride that have generally been tested

  • Fluoride & Liver Cancers in NTP Bioassay

    On October 28, 1988, Battelle Columbus Laboratories submitted its Final Report to the NTP concerning the results of the Mouse study. The principal finding of Battelle's report was that a dose-dependent increase of a rare liver cancer (hepatocholangiocarcinoma) had occurred in the fluoride-treated male and female mice.

  • NTP Bioassay on Fluoride/Cancer (1990)

    In 1977, the U.S. Congress requested that animal studies be conducted to determine if fluoride can cause cancer. The result of the Congressional request was an extensive animal study conducted in the 1980s by the National Toxicology Program (NTP) and published in 1990. The main finding of NTP's study was a dose-dependent increase in osteosarcoma (bone cancer) among the fluoride-treated male rats. 

  • A Critique of Gelberg's Study on Fluoride/Osteosarcoma in New York

    The case-control study by Gelberg, published first as a PhD dissertation and then later in two peer-reviewed journals, may represent the most substantive study on fluoride/osteosarcoma previous to Bassin’s 2001 analysis. In assessing Gelberg’s data, we were at first struck by the existence of several notable errors in both the thesis and papers. While these errors do raise questions about the study, our primary concern with Gelberg’s work relates to the methods she used to analyze her data.