Abstract
The accumulation in the skeleton of the ions of many elements that pass from the mammalian gastrointestinal tract into the general circulation is well known. This knowledge, however, strongly indicates that a grave medical menace may be in store for us, unless preventive measures, are. taken before it is too late. Specifically, the increasing concentration of Strontium-90, due to atomic fallout,
combined with fluoride, which is now being artificially added to some supplies of potable drinking water, could develop into a most serious health hazard. This article discusses the effects of radioactive elements in the human body, the process by which these elements are absorbed, and the possible additional hazards to future generations of an increase in radioactive material.
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Integrative analyses of key genes and regulatory elements in fluoride-affected osteosarcoma.
Osteosarcoma is one of the most malignant tumors in adolescents with severe outcomes while fluoride is one of the most abundant elements in the environment. Epidemiological evidence has elucidated the relationship between fluoride and osteosarcoma, but the molecular mechanisms are extremely complicated. Microarray profiles were downloaded from the Gene Expression
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European Commission: Opinions on the 2011 SCHER report on fluoridation for the Layman
European Commission: Opinions on the 2011 SCHER report on fluoridation for the Layman About this publication on Fluoridation Online at https://ec.europa.eu/health/scientific_committees/opinions_layman/fluoridation/en/about.htm 1. Source for this Publication The texts in level 3 are directly sourced from “Critical review of any new evidence on the hazard profile, health effects, and human exposure to fluoride and the fluoridating
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Revisiting the fluoride-osteosarcoma connection in the context of Elise Bassin's findings: part I
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A Case-Control Study of Fluoridation and Osteosarcoma.
Public health policy decisions in the United States have resulted in 62.4% of the population having access to fluoridated water. The purpose of this study was to examine the association between community water fluoridation and osteosarcoma. A secondary data analysis was performed with data collected from 2 separate but linked
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Revisiting the fluoride-osteosarcoma connection in the context of Elise Bassin's findings: part 2
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NTP Bioassay on Fluoride/Cancer (1990)
In 1977, the U.S. Congress requested that animal studies be conducted to determine if fluoride can cause cancer. The result of the Congressional request was an extensive animal study conducted in the 1980s by the National Toxicology Program (NTP) and published in 1990. The main finding of NTP's study was a dose-dependent increase in osteosarcoma (bone cancer) among the fluoride-treated male rats.
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Fluoride & Osteosarcoma: A Timeline
Several human epidemiological studies have found an association between fluoride in drinking water and the occurrence of osteosarcoma (bone cancer) in young males. These studies are consistent with the National Toxicology Program's (NTP) cancer bioassay which found that fluoride-treated male rats had an dose-dependent increase in osteosarcoma. Although a number of studies have failed to detect an association between fluoride and osteosarcoma, none of these studies have measured the risk of fluoride at specific windows in time, which based on recent results, is the critical question with respect to fluoride and osteosarcoma.
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A Critique of Gelberg's Study on Fluoride/Osteosarcoma in New York
The case-control study by Gelberg, published first as a PhD dissertation and then later in two peer-reviewed journals, may represent the most substantive study on fluoride/osteosarcoma previous to Bassin’s 2001 analysis. In assessing Gelberg’s data, we were at first struck by the existence of several notable errors in both the thesis and papers. While these errors do raise questions about the study, our primary concern with Gelberg’s work relates to the methods she used to analyze her data.
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Fluoride/Osteosarcoma Link Is Biologically Plausible
The "biological plausiblility" of a fluoride-osteosarcoma link is widely acknowledged in the scientific literature. The biological plausibility centers around three facts: 1) Bone is the principal site of fluoride accumulation, particularly during the growth spurts of childhood; 2) Fluoride is a mutagen when present at sufficient concentrations, and 3) Fluoride can stimulate the proliferation of osteoblasts (bone-forming cells).
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Fluoride's Mutagenicity: In vitro Studies
According to the National Toxicology Program, "the preponderance of evidence" from laboratory "in vitro" studies indicate that fluoride is a mutagenic compound. Many substances which are mutagens, are also carcinogens (i.e. they can cause cancer). As is typical for in vitro studies, the concentrations of fluoride that have generally been tested
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