Abstract
In continuing our studies on the effects of fluoride (F) on the toxicity of pesticides, we investigated the interaction of 1 ppm and 10 ppm F in the drinking water of rats orally administered 1 and 10 mg chlorpyriphos/kg bw/day, alone and in combination for 28 days. Changes in antioxidant parameters, along with protective effects of vitamins C, and E, were examined. Effects on superoxide dismutase, catalase, glutathione S transferase, glutathione peroxidase, glutathione, and lipid peroxidation were measured in the blood. Significant (p<0.05) alterations in these antioxidant indices were observed with repeated exposure of the rats to both toxicants alone and more so in combination. However, simultaneous oral administration of the antioxidant vitamins C and E in amounts of 60 and 100 mg/kg bw/day, respectively, afforded only partial protection against the subacute toxicity of F and chlorpyriphos alone and in combination.
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Reversal of fluoride induced cell injury through elimination of fluoride and consumption of diet rich in essential nutrients and antioxidants
The objective of the present communication is to address the issues concerning reversal of fluoride induced cell injury and disease (i.e. fluorosis) through the elimination of fluoride and consumption of a diet containing essential nutrients and antioxidants. Humans afflicted with fluorosis, as a result of consuming fluoride contaminated water or
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Cytoprotective effects of curcumin on sodium fluoride-induced intoxication in rat erythrocytes
Curcumin is well known for its potent antioxidant activity. The result of numerous studies showed that antioxidants can protect against fluoride-induced toxicity. In the present study, protective effects of curcumin against sodium fluoride-induced toxicity in rat erythrocytes were evaluated. Curcumin (10 and 20 mg/kg) and vitamin C (10 mg/kg) were
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Endogenous and exogenous antioxidants status in seminal plasma of skeletal fluorotic patients
Fluoride contamination in water (>1.5ppm) is the global problem for health in general. Fluoride has been reported to be a causative factor for male infertility. However, limited scientific literature is available on this aspect. The objective of the present study was to examine the fluoride induced oxidative burden and its
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Mitigating effects of some antidotes on fluoride and arsenic induced free radical toxicity in mice ovary
The effects of oral administration of sodium fluoride (NaF) and/or arsenic trioxide (As(2)O(3)) (5 mg and 0.5 mg/kg body weight, respectively) for 30 days were investigated on free radical induced toxicity in the mouse ovary. The reversibility of the induced effects after withdrawal of NaF+As(2)O(3) treatment and by administration of
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Antioxidant vitamin and mineral levels in sheep with fluorosis
The present study was carried out to determine the levels and changes of vitamins A, C, and E, fluoride, and calcium in 30 Morkaraman sheep with fluorosis, comparing them to unexposed healthy controls. The sheep exposed to fluoride showed significant differences in urinary fluoride and the blood levels of beta-carotene
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Nutrient Deficiencies Enhance Fluoride Toxicity
It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,
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Fluoride & Oxidative Stress
A vast body of research demonstrates that fluoride exposure increases oxidative stress. Based on this research, it is believed that fluoride-induced oxidative stress is a key mechanism underlying the various toxic effects associated with fluoride exposure. It is also well established that fluoride's toxic effects can be ameliorated by exposure
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Fluoride & Rickets
One of fluoride's most well-defined effects on bone tissue is it's ability to increase the osteoid (unmineralized bone) content of bone. When bones have too much osteoid, they become soft and prone to fracture -- a condition known as osteomalacia. When osteomalacia develops during childhood, it is called "rickets." The potential for fluoride
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Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism Excessive exposure to fluoride causes a defect of the tooth enamel known as dental fluorosis. In
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Mayo Clinic: Fluoridation & Bone Disease in Renal Patients
The available evidence suggests that some patients wtih long-term renal failure are being affected by drinking water with as little as 2 ppm fluoride. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers. The finding of adverse effects in patients drinking water with 2 ppm of fluoride suggests that a few similar cases may be found in patients imbibing 1 ppm, especially if large volumes are consumed, or in heavy tea drinkers and if fluoride is indeed the cause. It would seem prudent, therefore, to monitor the fluoride intake of patients with renal failure living in high fluoride areas.
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