Abstract
Rao and Thakur have shown that the antioxidants melatonin and alma (Emblica officinales, Indian gooseberry) are effective, both individually and in combination, against fluoride-induced genotoxicity in human peripheral blood lymphocyte cells, which was first described in humans in 1994. Some animal and
human work also suggests that fluoride (F) can impair the defensive response to genotoxicity by being deposited in high concentrations in the pineal gland and, through an enzyme-inhibiting action, reducing the secretion of melatonin, a powerful antioxidant able to eliminate free radicals and protect DNA. In having the capacity to be both genotoxic and impair melatonin secretion, F is similar to electromagnetic
radiation, at power line frequencies and above, and both have very low or zero thresholds for causing toxicity. In view of the seriousness of neoplasia, the effect of fluoride on melatonin secretion warrants further research.
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Fluoride-induced oxidative stress in rat's brain and its amelioration by buffalo (Bubalus bubalis) pineal proteins and melatonin.
Fluoride (F) becomes toxic at higher doses and induces some adverse effects on various organs, including brain. The mechanisms underlying the neurotoxicity caused by excess fluoride still remain unknown. The aims of this study were to examine F-induced oxidative stress (OS) and role of melatonin (MEL) and buffalo pineal proteins
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Melatonin ameliorates fluoride induced neurotoxicity in young rats: an in vivo evidence
Objective: Developing brain is highly vulnerable to environmental toxins. Recently, fluoride was declared as a developmental neurotoxin and heralded search for natural neuroprotectant. In the present study, we have evaluated the neuroprotective and anti-inflammatory efficacy of melatonin in fluoride induced neurotoxicity. Methods: Animals were divided into following groups; the first group
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Effect of pineal proteins at different dose level on fluoride-induced changes in plasma biochemicals and blood antioxidants enzymes in rats
Pineal glands secrets melatonin and various proteins and peptides which has many physiological functions. In keeping with this view, present experiment was conducted to know the effect of buffalo (Bubalus bubalis) pineal proteins (PP) at different dose level on fluoride-induced changes in plasma biochemicals and blood antioxidants enzymes in female
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Protective effect of lycopene on fluoride-induced ameloblasts apoptosis and dental fluorosis through oxidative stress-mediated Caspase pathways
Fluoride is an environmental toxicant and induces dental fluorosis and oxidative stress. Lycopene (LYC) is an effective antioxidant that is reported to attenuate fluoride toxicity. To determine the effects of LYC on sodium fluoride (NaF) -induced teeth and ameloblasts toxicity, rats were treated with NaF (10 mg/kg) and/or LYC (10 mg/kg) by
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Evaluation of caspase-dependent apoptosis during fluoride-induced liver lesion in pigs
Sixteen barrows (Duroc x Landrace x Yorkshire) were randomly divided into two groups, each consisting eight pigs. The groups received the same basal diet supplemented with 0 and 400 mg/kg fluoride, respectively. Histological examinations, including in situ terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL), Haematoxylin and Eosin staining (HE)
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Luke (2001): Fluoride Deposition in the Aged Human Pineal Gland
This study has added new knowledge on the fate and distribution of fluoride in the body. It has shown for the first time that fluoride readily accumulates in the human pineal gland although there was considerable inter-individual variation
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Nutrient Deficiencies Enhance Fluoride Toxicity
It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,
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Fluoride & Oxidative Stress
A vast body of research demonstrates that fluoride exposure increases oxidative stress. Based on this research, it is believed that fluoride-induced oxidative stress is a key mechanism underlying the various toxic effects associated with fluoride exposure. It is also well established that fluoride's toxic effects can be ameliorated by exposure
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Luke (1997): The Effect of Fluoride on the Physiology of the Pineal Gland (Excerpts)
"The results suggest that fluoride is associated with low circulating levels of melatonin and this leads to an accelerated sexual maturation in female gerbils. The results strengthen the hypothesis that the pineal has a role in pubertal development."
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Fluoride content in tea and its relationship with tea quality.
J Agric Food Chem. 2004 Jul 14;52(14):4472-6. Fluoride content in tea and its relationship with tea quality. Lu Y, Guo WF, Yang XQ. Department of Tea Science, Zhejiang University, 268 Kaixuan Road, Hangzhou 310027, People's Republic of China. Abstract: The tea plant is known as a fluorine accumulator. Fluoride (F) content in fresh leaves collected
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