Abstract

Fluoride contamination in water (>1.5ppm) is the global problem for health in general. Fluoride has been reported to be a causative factor for male infertility. However, limited scientific literature is available on this aspect. The objective of the present study was to examine the fluoride induced oxidative burden and its association with endogenous and exogenous antioxidant status in seminal plasma of different grade of fluorotic patients (mild, moderate and severe). The lipid peroxide levels and antioxidant status namely superoxide dismutase, catalase, glutathione vitamins (A, C and E) were investigated in seminal plasma. Result of the present study showed that the LPO was found to be gradually increased with severity of the disease. The endogenous and exogenous antioxidants were found to be decreased in severe florotic patients. On the basis of the results it may conclude that fluoride exposure promote oxidative stress and alteration in vitamins in seminal plasma. These alterations may induce pathophysiological activities due to lack of vitamin and antioxidant defense against ROS. However, further in depth studies is required for the understanding of pathophysiology of Fluorosis.

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