Abstract
As fluoride inhibits Glycolysis we conducted a preliminary study to analyse the effect of fluoride on blood glucose in the individuals of endemic fluorosis area .
The study was conducted to correlate the serum fluoride with blood glucose levels in a population living in endemic fluorosis area
The present study included serum samples of 104 male and female of various age groups 20 – 70 yrs. The patients had attended OPD of Kamineni Institute of medical sciences hospital and advised for RBS. Blood glucose was estimated by hexokinase method using Dade Behring Dimension AR. Serum fluoride was estimated using ion selective electrode ECOSAN statistical analysis was done by using SPSS software.
Based on our findings, we made 3 different groups .Group-I comprised of both having increased RBS and fluoride levels(Males 4%, Females 5%) Group II comprised of patients having increased serum fluoride levels with normo glycemia (Males 44% Females 44%) and Group III consisted of patients having hyper glycemia and normal fluoride ( Males 8% Females 1%).Results obtained were compared between groups I,II,III.
There was no significant correlation between serum fluoride and hyper glycemia in endemic fluorosis area. This could be due to less sample number. None the less we are still continuing with the study.
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Effect of sodium fluoride on bone biomechanical and histomorphometric parameters and on insulin signaling and insulin sensitivity in ovariectomized rats
Osteoporosis is a systemic disease characterized by bone degradation and decreased bone mass that promotes increased bone fragility and eventual fracture risk. Studies have investigated the use of sodium fluoride (NaF) for the treatment of osteoporosis. However, fluoride can alter glucose homeostasis. The aim of this study was to evaluate
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[Changes in bone mass and in glucose homeostasis in subjects with high spontaneous fluoride intake]
This paper reports metabolic data of 24 women and two men, 44-66 years old, ex-residents in an area of endemic fluorosis close to Bahía Blanca city. Fasting fluoremias of these subjects (0.5 to 9.2 microM) and daily urinary fluoride excretion (> 60 mumoles/day) are characteristics of zones with endemic fluorosis.
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Comparative study of the effect of sodium fluoride and sodium monofluorophosphate on glucose homeostasis in the rat.
The effect of acute and chronic administration of sodium fluoride (NaF) or sodium monofluorophosphate (MFP) on the glucose homeostasis of the rat are compared. The oral administration of a single dose of 40 mumol/100 g b.w. of either compound produced similar increases in plasma glucose (up to 1.8 g/l) and
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Fluoride-induced resistance to insulin in the rat.
The insulinic response of rats challenged with glucose at different times after an oral dose of 40 µmol NaF/100 g bw revealed the concentration of the molecular species reacting with anti-insulin antibody was significantly lower after 3 hr, and the glucose levels were somewhat higher than in controls. At the
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Reversible impairment of glucose tolerance in patients with endemic fluorosis. Fluoride Collaborative Study Group.
Endemic fluorosis is a condition resulting from prolonged ingestion of drinking water which contains excess fluoride. Studies on rats have suggested that fluoride toxicity may produce glucose intolerance and abnormalities in insulin secretion. We studied glucose and insulin profiles following an oral glucose load in patients with endemic fluorosis. Twenty-five
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Fluoride & Insulin
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Fluoride & Impaired Glucose Tolerance
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NRC (2006): Fluoride's Effect on Glucose Metabolism
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Fluoride Sensitivity Among Diabetics
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Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus
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