Abstract
As fluoride inhibits Glycolysis we conducted a preliminary study to analyse the effect of fluoride on blood glucose in the individuals of endemic fluorosis area .
The study was conducted to correlate the serum fluoride with blood glucose levels in a population living in endemic fluorosis area
The present study included serum samples of 104 male and female of various age groups 20 – 70 yrs. The patients had attended OPD of Kamineni Institute of medical sciences hospital and advised for RBS. Blood glucose was estimated by hexokinase method using Dade Behring Dimension AR. Serum fluoride was estimated using ion selective electrode ECOSAN statistical analysis was done by using SPSS software.
Based on our findings, we made 3 different groups .Group-I comprised of both having increased RBS and fluoride levels(Males 4%, Females 5%) Group II comprised of patients having increased serum fluoride levels with normo glycemia (Males 44% Females 44%) and Group III consisted of patients having hyper glycemia and normal fluoride ( Males 8% Females 1%).Results obtained were compared between groups I,II,III.
There was no significant correlation between serum fluoride and hyper glycemia in endemic fluorosis area. This could be due to less sample number. None the less we are still continuing with the study.
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Vitamin D deficiency in patients with diabetes and its correlation with water fluoride levels.
Chronic exposure to fluoride through drinking water has been linked to insulin resistance and resulting type 2 diabetes mellitus (T2DM). Here, we aim to study the impact of water fluoride levels on blood glucose and vitamin D levels. A hospital-based study was conducted on diabetic patients (n = 303) at
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Reversible impairment of glucose tolerance in patients with endemic fluorosis. Fluoride Collaborative Study Group.
Endemic fluorosis is a condition resulting from prolonged ingestion of drinking water which contains excess fluoride. Studies on rats have suggested that fluoride toxicity may produce glucose intolerance and abnormalities in insulin secretion. We studied glucose and insulin profiles following an oral glucose load in patients with endemic fluorosis. Twenty-five
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Comparative study of the effect of sodium fluoride and sodium monofluorophosphate on glucose homeostasis in the rat.
The effect of acute and chronic administration of sodium fluoride (NaF) or sodium monofluorophosphate (MFP) on the glucose homeostasis of the rat are compared. The oral administration of a single dose of 40 mumol/100 g b.w. of either compound produced similar increases in plasma glucose (up to 1.8 g/l) and
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Topical fluorides: effects on physiologic and biochemical processes
The ingestion of fluoride from dentifrices or mouthrinses can contribute substantially to the total daily intake of the ion, even in communities that provide optimally fluoridated drinking water. It is concluded that the frequent and unsupervised use of these products by children six years of age or younger, especially those living in
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Physical exercise ameliorates the toxic effect of fluoride on the insulin-glucose system.
Daily intake of water with fluoride concentrations >1.5 mg/l produces insulin resistance (IR). On the other hand, physical activity increases insulin sensitivity in the muscle. Therefore, the aim of this study was to evaluate the effect of physical activity on IR in rats treated with sodium fluoride (NaF) in drinking
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Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus
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NRC (2006): Fluoride's Effect on Glucose Metabolism
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