Fluoride induced biochemical changes in reproductive organs of male mice

Abstract

Adult male albino mice were given 10 mg and 20 mg/kg body weight of NaF for 30 days. NaF caused a decrease in body weight, but no change in organ weight, except for the prostate gland and seminal vesicles. No significant change in testis cholesterol and serum testosterone levels occurred. However, in the testis succinic dehydrogenase levels decreased, in the epididmides sialic acid and ATPase levels decreased; in the vas deferens glycogen levels increased, seminal vesicles fructose levels increased in the prostate glands acid phosphatase and total protein levels increased. After withdrawal of treatment for a period of two months the levels of these substances returned to normal.