Summary: Decreasing of the insulin concentration and increasing of the C-peptide level in blood serum of 72 workers of cryolytes industries detected by radioimmunilogical method. These changes were caused by the fluorine intoxication of workers.
[T]he analysis of the results obtained and secondary data allow us to conclude that the pancreas is not unaffected during CFI. For the first time we have provided a complex characteristic of insulin, G and C-peptide contents in the blood serum of people during CFI [chronic fluoride intoxication], which evidenced moderate hypoinsulinemia accompanied by normal or slightly elevated G and glucose levels. Hormonal status changes reflect the complex mechanism of direct or indirect fluoride impact on the production and metabolism of insular hormones. The dynamic of lowering insulin concentration in the blood of fluorosis patients, depending on the intoxication stage, accompanied by a tendency for hypoglycemia, requires more detailed attention, since modern interpretations dictate that absolute or relative insulin deficiency determines the development of diabetes mellitus, triggers disruptions in carbohydrate, fat and protein exchanges and liver function. Further clinical lab and hormonal studies should more fully evaluate the role of the pancreas in CFI pathogenesis and of fluoride as a diabetes-inducing factor…
1. Cryolite industry workers exhibit moderate hypoinsulinemia accompanied by normal G levels and a verifiable C-peptide concentration increase.
2. A tendency was discovered for insulin levels to decrease depending on the duration of exposure of workers to fluoride compounds at the CFI [Chronic Fluoride Intoxification] stage.
3. Changes in the hormonal state reflect the complex mechanism of direct or indirect fluorides impact on the production and metabolism of insular hormones.