Abstract

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    The present study was undertaken to evaluate the effect of fluoride toxicity on the reproductive system of male rats. Sexually mature male Wistar rats were exposed to 2, 4, and 6 ppm sodium fluoride in their drinking water for 6 months ad libitum. Sperm motility and density in cauda epididymis

  • Reversible fluoride induced fertility impairment in male mice

    Sodium fluoride (NaF) fed to adult male albino mice at a dose of 10 mg and 20 mg/kg body weight, caused a significant decrease in sperm county and motility. Scanning electron microscopy and silver nitrte staining showed large numbers of deflagellated spermatozoa, with acrosomal, midpiece and tail abnormalities. The treatment

  • NaF may disturb male fertility in rodents

    An increase in the potential for lipoperoxidation in the rat testis and a decrease in rodents fertility by NaF has been reported (Pinto et al., 1997, Pharm. Toxicol., 80, III, 117; Chinoy et al., 1992, J. Environ. Biol 13, 55). However, other authors described that spermatogenesis in the rat is

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  • Fluoride reduced CRISP 2 expression in testis and epididymal sperm of rats.

    Fluorine, an active element which is widely distributed in the environment, has been demonstrated to have adverse effects on male reproductive systems at a high dose. The objective of the present study was to explore the key role of cysteine-rich secretory protein (CRISP)2 in fluoride-induced male reproductive toxicity by investigating,

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  • Fluoride's Effect on Male Reproductive System: Animal Studies

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  • Fluoride's Effect on Male Reproductive System - Human Studies

    Consistent with in vitro and animal research, studies of human populations have reported associations between fluoride exposure and damage to the male reproductive system. Most notably, a scientist at the Food & Drug Administration reported in 1994 that populations in the United States with more than 3 ppm fluoride in their water had lower "total fertility rates" than populations with lower fluoride levels.

  • Fluoride's Effect on the Male Reproductive System -- In Vitro Studies

    Carefully controlled in vitro studies have found that direct exposure of fluoride to the testes or semen inhibits testosterone production and damages sperm. While researchers have known since the 1930s that mega concentrations of fluoride can completely (but reversibly) immobilize sperm, it was not until the 1970s and 1980s that researchers found that relatively modest concentrations of fluoride could cause damage prior to complete immobilization.

  • Fluoride's Effect on Male Reproductive System -- The "Sprando/Collins" Anomaly

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