Abstract
The therapeutic effects of ascorbic acid and calcium (Ca2+) supplementation on reproductive functions of fluoride-treated (10 mg/kg body weight) male rats were investigated. Sodium fluoride treatment resulted in a decrease in almost all parameters studied except concentration of testicular cholesterol, which implies that androgen synthesis might not be affected by NaF treatment. Succinate dehydrogenase activity decreased in testis suggesting that its oxidative metabolism was altered by NaF treatment. Adenosine triposphatase activity, protein, and sialic acid levels in caput and cauda epididymides also showed a decrease. All these changes resulted in a significant decrease in sperm motility and thereby fertility rate. Glycogen concentrations in vas deferens were altered, probably due to impaired metabolic turnover. The fructose levels in vas deferens and seminal vesicle as well as the acid phosphatase activity in ventral prostate were also decreased significantly by NaF treatment.
On the other hand, simultaneous treatment of NaF along with ascorbic acid or calcium resulted in recovery in all the affected parameters studied. The recovery was more significant after treatment with ascorbic acid than with calcium. Therefore, ascorbic acid and calcium may be useful for amelioration of fluoride toxicity in endemic areas.
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Reversal of fluoride-induced alteration in cauda epididymal spermatozoa and fertility impairment in male mice
The effects of sodium fluoride (NaF) ingestion (10 mg NaF/kg body weight) and the possible therapeutic effects of ascorbic acid (AA, 15 mg/animal/day) and/or calcium phosphate (Ca, 25 mg/animal/day) on the reproductive functions and fertility of male mice were investigated. NaF-ingestion brought about a significant decline in sperm acrosomal acrosin
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Efects of sodium fluoride and aluminium chloride on ovary and uterus of mice and their reversal by some antidotes
A study was made of the effects on ovary and uterus of adminis-tering sodium fluoride (10 mg/kg body weight) or aluminium chloride (200 mg/kg body weight) alone and in combination to female albino mice (Mus musculus) for 30 days. The reversibility of the induced effects by withdrawal of NaF +
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Endemic genu valgum and other bone deformities in two villages of Mandla district in central India
An epidemiological investigation was undertaken in the villages of Tilaipani and Hirapur located in Mandla District of Central India to determine the cause and extent of a peculiar skeletal deformity characterised by knock knee (genu valgum) occurring mainly among children. In Tilaipani, 74.4% of children and adolescents below age 20
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Fluoride toxicity on rat testis and cauda epididymal tissue components and its reversal
The toxic effects were evaluated of sodium fluoride (NaF) ingestion on the physiology of tissue components of testis and epididymis of adult, male albino rats, and the possible reversal of the effects by use of some antidotes. The results revealed that the testis and cauda epididymal proteins were altered, with
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Effective interventional approach to control anaemia in pregnant women
Anaemia in pregnancy and low birth weight babies, a serious public health problem, troubles India and several other nations. This article reports the results of a approach to address the issue. Women up to 20 week pregnancy with haemoglobin (Hb) 9.0 g/dl or less, those with urinary fluoride beyond 1.0
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Nutrient Deficiencies Enhance Fluoride Toxicity
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Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism Excessive exposure to fluoride causes a defect of the tooth enamel known as dental fluorosis. In
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Fluoridation, Dialysis & Osteomalacia
In the 1960s and 1970s, doctors discovered that patients receiving kidney dialysis were accumulating very high levels of fluoride in their bones and blood, and that this exposure was associated with severe forms of osteomalacia, a bone-softening disease that leads to weak bones and often excruciating bone pain. Based on
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Skeletal Fluorosis & Individual Variability
One of the common fallacies in the research on skeletal fluorosis is the notion that there is a uniform level of fluoride that is safe for everyone in the population. These "safety thresholds" have been expressed in terms of (a) bone fluoride content, (b) daily dose, (c) water fluoride level, (d) urinary fluoride level, and (e) blood fluoride level. The central fallacy with each of these alleged safety thresholds, however, is that they ignore the wide range of individual susceptibility in how people respond to toxic substances, including fluoride.
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Fluoride & Rickets
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