Abstract
The therapeutic effects of ascorbic acid and calcium (Ca2+) supplementation on reproductive functions of fluoride-treated (10 mg/kg body weight) male rats were investigated. Sodium fluoride treatment resulted in a decrease in almost all parameters studied except concentration of testicular cholesterol, which implies that androgen synthesis might not be affected by NaF treatment. Succinate dehydrogenase activity decreased in testis suggesting that its oxidative metabolism was altered by NaF treatment. Adenosine triposphatase activity, protein, and sialic acid levels in caput and cauda epididymides also showed a decrease. All these changes resulted in a significant decrease in sperm motility and thereby fertility rate. Glycogen concentrations in vas deferens were altered, probably due to impaired metabolic turnover. The fructose levels in vas deferens and seminal vesicle as well as the acid phosphatase activity in ventral prostate were also decreased significantly by NaF treatment.
On the other hand, simultaneous treatment of NaF along with ascorbic acid or calcium resulted in recovery in all the affected parameters studied. The recovery was more significant after treatment with ascorbic acid than with calcium. Therefore, ascorbic acid and calcium may be useful for amelioration of fluoride toxicity in endemic areas.
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Efects of sodium fluoride and aluminium chloride on ovary and uterus of mice and their reversal by some antidotes
A study was made of the effects on ovary and uterus of adminis-tering sodium fluoride (10 mg/kg body weight) or aluminium chloride (200 mg/kg body weight) alone and in combination to female albino mice (Mus musculus) for 30 days. The reversibility of the induced effects by withdrawal of NaF +
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Reversal of fluoride-induced alteration in cauda epididymal spermatozoa and fertility impairment in male mice
The effects of sodium fluoride (NaF) ingestion (10 mg NaF/kg body weight) and the possible therapeutic effects of ascorbic acid (AA, 15 mg/animal/day) and/or calcium phosphate (Ca, 25 mg/animal/day) on the reproductive functions and fertility of male mice were investigated. NaF-ingestion brought about a significant decline in sperm acrosomal acrosin
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Fluoride and aluminum induced toxicity in mice epididymis and its mitigation by vitamin C
Treatment of adult male mice with sodium fluoride (NaF, 10 mg/kg bw/day) and aluminium chloride (AlCl3, 200 mg/kg bw/day) simultaneously for 30 days caused marked histological changes in the epididymis accompanied by decreased levels of protein and sialic acid and also lowered activities of adenosine triphosphatase (ATPase) and succinate dehydrogenase
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Effect of fluoride on reactive oxygen species and bone metabolism in postmenopausal women.
A study was made of the effects of fluoride (F) on the antioxidant defense systems of postmenopausal women residing in a fluorotic and a nonfluorotic village in Chitoor district, Andhra Pradesh, India. Twenty-five postmenopausal women (approximately 10 years postmenopause, mean age 57 years) residing in endemic fluorotic Adharam and nonfluorotic
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Mitigating effects of some antidotes on fluoride and arsenic induced free radical toxicity in mice ovary
The effects of oral administration of sodium fluoride (NaF) and/or arsenic trioxide (As(2)O(3)) (5 mg and 0.5 mg/kg body weight, respectively) for 30 days were investigated on free radical induced toxicity in the mouse ovary. The reversibility of the induced effects after withdrawal of NaF+As(2)O(3) treatment and by administration of
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Skeletal Fluorosis & Individual Variability
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Fluoride Exposure Increases Metabolic Requirement for Calcium & Vitamin D
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Unheeded Warnings: Government Health Authorities Ignore Fluoride Risk for Kidney Patients
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