Abstract
The study was designed in order to assess the relationship between infertility and histological structure of testes following administration of varying doses of sodium fluoride. One hundred adult male albino mice were fed 10 ppm (Group A), 500 ppm (Group B) and 1000 ppm (Group C) of sodium fluoride in drinking water. The Group A animals were sacrificed at the end of one month, Group B after two and Group C after three months. The testes were removed and, after being processed in the usual manner, they were stained with hematoxylin and eosin. In Groups B and C, the higher dosage groups, there was a lack of maturation and differentiation of spermatocytes. In animals sacrificed at the end of three months, spermatogenesis had stopped and the seminiferous tubules had become necrotic. A definite relationship between fluorosis and damage to the testes has, therefore, been established by this study.
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Exposure to high fluoride concentration in drinking water will affect spermatogenesis and steroidogenesis in male albino rats
Sodium fluoride (NaF) administered orally to adult male rats at a dose level of 4.5 ppm and 9.0 ppm for 75 days caused significant decrease in the body weight, brain index and testicular index. A significant decrease in sperm count, sperm motility, sperm viability and sperm function (HOS positive) with
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Sodium Fluoride In Vitro Treatment Affects the Expression of Gonadotropin and Steroid Hormone Receptors in Chicken Embryonic Gonads.
Sodium fluoride (NaF), in addition to preventing dental decay may negatively affect the body. The aim of this study was to examine the effect of a 6 h in vitro treatment of gonads isolated from 14-day-old chicken embryos with NaF at doses of 1.7 (D1), 3.5 (D2), 7.1 (D3), and
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Fluoride altered rat's blood testis barrier by affecting the F-actin via IL-1a.
Highlights Fluoride affected the function and ultra-structure of BTB in the testis. Fluoride induced F-actin bundles into highly branched arrangement. Fluoride markedly increased the expression level of actin related protein 3(Arp3). IL-1a induced the damage of BTB in the rat exposed to fluoride for 30 days. Fluoride is known to
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Fluoride toxicity in the testis and cauda epididymis of guinea pig and reversal by ascorbate
Effects of sodium fluoride (NaF) (30 mg kg-1 body weight) and ascorbic acid ingestion along with sodium fluoride for 30 days each were studied to evaluate its possible role as an ameliorative agent on functions of reproductive organs and spermatozoa of the fluorotic guinea pig. The cauda epididymal spermatozoa were
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Antagonistic effect of calcium against fluorosis induced oxidative stress in rat testis
[Objective] To investigate the effects of fluoride on catalase (CAT) , lactate dehydrogenase (LDH) , and malonic dialdehyde (MDA) in rat testis and the potential antagonism against these effects by calcium. [Methods] Eighty healthy male SD rats were equally randomized into 10 groups: 1 control group, 6 fluorosis groups with
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Fluoride's Effect on Male Reproductive System - Human Studies
Consistent with in vitro and animal research, studies of human populations have reported associations between fluoride exposure and damage to the male reproductive system. Most notably, a scientist at the Food & Drug Administration reported in 1994 that populations in the United States with more than 3 ppm fluoride in their water had lower "total fertility rates" than populations with lower fluoride levels.
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Fluoride's Effect on Male Reproductive System: Animal Studies
Over 60 studies on animals (including rats, mice, roosters, and rabbits) have found that fluoride adversely impacts the male reproductive system. These studies have repeatedly found the following effects: (1) decreases in testosterone levels; (2) reduced sperm motility; (3) altered sperm morphology; (4) reduced sperm quantity; (5) increased oxidative stress; (6) and reduced capacity to breed.
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Fluoride's Effect on the Male Reproductive System -- In Vitro Studies
Carefully controlled in vitro studies have found that direct exposure of fluoride to the testes or semen inhibits testosterone production and damages sperm. While researchers have known since the 1930s that mega concentrations of fluoride can completely (but reversibly) immobilize sperm, it was not until the 1970s and 1980s that researchers found that relatively modest concentrations of fluoride could cause damage prior to complete immobilization.
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Fluoride's Effect on Male Reproductive System -- The "Sprando/Collins" Anomaly
In contrast to the findings of over 60 animal studies from other research teams, a series of studies by FDA researchers Sprando & Collins reported virtually no evidence of reproductive toxicity among animals treated with very high levels of fluoride exposure. The reasons for this discrepancy remains unclear. Excerpts from Sprando/Collins' Studies: "This study
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