Abstract
The percentage of spermatozoa in ram semen with intact acrosomes and the level of spermatozoa motility decreased significantly after dilution and after 5 hr incubation at 38ºC. Both indices decreased significantly in the presence of NaF at concentrations ranging from 20 µmol/L to 0.1 mol/L. The activities of androgen-dependent enzymes—acid phosphatase (ACP), lactate dehydrogenase (LDH), and gamma-glutamyl transferase (y-GT-10S)—decreased significantly when the ejaculate was treated with NaF at concentrations of 20, 100, 200 µmol/L (0.38; 1.9; 3.8 ppm F-), but they returned to the initial value of the control at 0.1 mol/L (1900 ppm F-). The activity of aspartate transaminase (AspAT) displayed a large increase with the increasing lower F-concentrations and then showed a substantial decrease in activity at the high F- concentration. These changes undoubtedly affect the physiological functions of the sperm.
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Exposure to high fluoride concentration in drinking water will affect spermatogenesis and steroidogenesis in male albino rats
Sodium fluoride (NaF) administered orally to adult male rats at a dose level of 4.5 ppm and 9.0 ppm for 75 days caused significant decrease in the body weight, brain index and testicular index. A significant decrease in sperm count, sperm motility, sperm viability and sperm function (HOS positive) with
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Changes caused by fluoride and lead in energy metabolic enzyme activities in the reproductive system of male offspring rats.
To assess effects of fluoride (F) and lead (Pb) on the energy metabolism of the male reproductive system, the activities of lactate dehydrogenase (LDH), succinate dehydrogenase (SDH), adenosine triphosphatase (ATPase), and Gamma-glutamyltranspeptidase (?-GT), along with sperm quality and testicular histology, were determined at week 6, 8, 10, and 12 in male offspring rat pups exposed
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NADPH oxidase participates in the oxidative damage caused by fluoride in rat spermatozoa. Protective role of a-tocopherol
Fluorosis, caused by drinking water contaminated with inorganic fluoride, is a public health problem in many areas around the world. The aim of this study was to evaluate oxidative stress in spermatozoa caused by fluoride and NADPH oxidase in relationship to fluoride. Four experimental groups of male Wistar rats were
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Effects of fluoride ingestion on the physiology of reproductive organs of male rat
Oral administration of sodium fluoride (NaF) (5 and 10 mg/kg body weight/day) for 30 days to adult male rats, brought about a reduction in body weight especially by high dose (10 mg/kg body weight). In fluorotic rats, testicular cholesterol and serum testosterone levels were not affected. However, succinate dehydrogenase activity
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Fluoride toxicity in the testis and cauda epididymis of guinea pig and reversal by ascorbate
Effects of sodium fluoride (NaF) (30 mg kg-1 body weight) and ascorbic acid ingestion along with sodium fluoride for 30 days each were studied to evaluate its possible role as an ameliorative agent on functions of reproductive organs and spermatozoa of the fluorotic guinea pig. The cauda epididymal spermatozoa were
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Fluoride's Effect on the Male Reproductive System -- In Vitro Studies
Carefully controlled in vitro studies have found that direct exposure of fluoride to the testes or semen inhibits testosterone production and damages sperm. While researchers have known since the 1930s that mega concentrations of fluoride can completely (but reversibly) immobilize sperm, it was not until the 1970s and 1980s that researchers found that relatively modest concentrations of fluoride could cause damage prior to complete immobilization.
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Fluoride's Effect on Male Reproductive System -- The "Sprando/Collins" Anomaly
In contrast to the findings of over 60 animal studies from other research teams, a series of studies by FDA researchers Sprando & Collins reported virtually no evidence of reproductive toxicity among animals treated with very high levels of fluoride exposure. The reasons for this discrepancy remains unclear. Excerpts from Sprando/Collins' Studies: "This study
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Fluoride's Effect on Male Reproductive System: Animal Studies
Over 60 studies on animals (including rats, mice, roosters, and rabbits) have found that fluoride adversely impacts the male reproductive system. These studies have repeatedly found the following effects: (1) decreases in testosterone levels; (2) reduced sperm motility; (3) altered sperm morphology; (4) reduced sperm quantity; (5) increased oxidative stress; (6) and reduced capacity to breed.
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Fluoride's Effect on Male Reproductive System - Human Studies
Consistent with in vitro and animal research, studies of human populations have reported associations between fluoride exposure and damage to the male reproductive system. Most notably, a scientist at the Food & Drug Administration reported in 1994 that populations in the United States with more than 3 ppm fluoride in their water had lower "total fertility rates" than populations with lower fluoride levels.
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