Abstract

In experiments with 76 rats it was demonstrated that withdrawal of fluoride from fluoride-intoxicated rats caused an improvement in the interstitial inflammation and a marked reduction of the dilated convoluted tubules and Henle loops of the kidney.

• Related Studies :

  • Chronic Kidney Disease in the United States, 2019

    With chronic kidney disease (CKD), kidneys become damaged over time or cannot clean the blood as well as healthy kidneys. When the kidneys don’t work well, wastes and extra water build up in the body and may cause other health problems, including heart disease and high blood pressure. However, people

  • Investigation on the effect of Hibiscus Sabdariffa calyxethanolic extract on sodium fluoride induced fluorosis in rats

    Flu o rosis was induced by the oral administration of Sodium Fluoride (10mg/kg) for 30 days. On 30th day the Flurosis was confirmed by studying the level of fluorine in serum and urine. Treatment was started from 30th day to 60th day by ingesting Hibiscus Sabdariffa calyxethanolic extract 200 mg/kg and

  • Protective effect of Tamarindus indica fruit pulp extract on collagen content and oxidative stress induced by sodium fluoride in the liver and kidney of rats

    Fluorosis is a serious public health problem in many parts of the world. The generation of reactive oxygen species and lipid peroxidation has been considered to play an important role in the pathogenesis of chronic fluoride toxicity. The present study was undertaken to evaluate the protective effect of Tamarindus indicafruit pulp extract

  • Fluoride-induced histopathology and synthesis of stress protein in liver and kidney of mice

    Selective low (15 mg sodium fluoride (NaF)/L) and relatively high (150 mg NaF/L) doses of in vivo fluoride (F) treatment to Swiss albino mice through drinking water elicited organ-specific toxicological response. All the F-exposed groups showed severe alterations in both liver and kidney architectures, but there was no significant change

  • Changes in fluoride levels in the liver, kidney, and brain and in neurotransmitters of mice after subacute administration of fluoride

    The effects of fluoride after subacute oral administration of NaF at levels of 0, 1, 5, 25, and 125 ppm F– were evaluated in adult male BALB/c mice. Fluoride levels in the murine liver, kidney, and cerebrum after one month were determined using a highly sensitive flow-injection apparatus with a

• Related FAN Content :

  • Fluoride as a Cause of Kidney Disease in Animals

    Because the kidney is exposed to higher concentrations of fluoride than all other soft tissues (with the exception of the pineal gland), there is concern that excess fluoride exposure may contribute to kidney disease - thus initiating a "vicious cycle" where the damaged kidneys increase the accumulation of fluoride, causing in

  • Fluoride & Kidney Stones

    It has long been suspected that fluoride may contribute to the formation of kidney stones. This suspicion has recently gained support from a study of an American man with skeletal fluorosis. According to the authors: "A new, important, medical problem (that seemed temporally related to cessation of fluoride exposure and subsequent negative calcium

  • Fluoride as a Cause of Kidney Disease in Humans

    Because the kidney is exposed to higher concentrations of fluoride than all other soft tissues (with the exception of the pineal gland), there is concern that excess fluoride exposure may contribute to kidney disease - thus initiating a "vicious cycle" where the damaged kidneys increase the accumulation of fluoride, causing

  • Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence

    A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.

  • Fluoride Gels & Kidney Function

    Scientists have found that the application of "Fluoride Gels" at the dental office causes very high spikes in the blood fluoride level. The high spikes in blood fluoride levels are a result of three factors: the high concentration of fluoride in the gel (= 12.3 mg of fluoride in each