Abstract
The effect of fluoride on the physical properties of bone was investi- gated with the aid of an Instron materials tester. Two groups of weanling female rats, one on an adequate (0.6% ) calcium diet and the other on a low (0.1%) diet were given the following dosage levels of fluoride (as NaF) in their deionized drinking water over a fifteen End one-half week period: 3.4 ppm, 10.0 ppm and 45.0 ppm. In the adequate calcium group a significant increase in flexibility in the rat femur was found only at the 45.0 ppm dosage level. This was not offset by a significant decrease in strength. In the low calcium group a similar significant increase in flexibility appeared at the 10.0 ppm dosage level 2s well as the 45.0 ppm, but a significant decrease in strength at the two dosage levels was observed. These were in direct relation to the amount of fluoride given.
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High fluoride and low calcium levels in drinking water is associated with low bone mass, reduced bone quality and fragility fractures in sheep
Chronic environmental fluoride exposure under calcium stress causes fragility fractures due to osteoporosis and bone quality deterioration, at least in sheep. Proof of skeletal fluorosis, presenting without increased bone density, calls for a review of fracture incidence in areas with fluoridated groundwater, including an analysis of patients with low bone
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Combined effects of diets with reduced calcium and phosphate and increased fluoride intake on vertebral bone strength and histology in rats
Ingested fluoride is incorporated into bone apatite and can affect the structural integrity of bone. Fluoride absorption in the gut and incorporation into bone is affected by the presence of other ions, including calcium. We hypothesized that a low calcium phosphate diet combined with high fluoride intake would have independent
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On fluoride and bone strength
We welcome the opportunity to respond to the letter by Baylink et al. Their letter makes many good points but, unfortunately, it also contains several misinterpretations of our analysis. The thesis of Baylink's letter and the paper of Einhorn et al. [1] is that fluoride incorporation into cortical bone does
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Effects of estrogen on bone composition in rats at low and high fluoride intake
Bone examinations were carried out on female rats which had received estradiol benzoate and drinking water containing either 0.55 or 50 ppm of fluoride (F). The estradiol benzoate was injected subcutaneously twice weekly and the rats were killed after 2, 4 and 6 weeks. The results showed that estrogen treatment
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The effect of fluoride supplementation on the strength of osteopenic bone
The strength of osteopenic bone from calcium deprived rats, quail and roosters was significantly reduced after fluoride supplementation. Using a device which measures torque, femurs from rats fed low calcium diets with 100 parts per million fluoride added to the water supply fractured at lower torque values than those values
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Nutrient Deficiencies Enhance Fluoride Toxicity
It has been known since the 1930s that poor nutrition enhances the toxicity of fluoride. As discussed below, nutrient deficiencies have been specifically linked to increased susceptibility to fluoride-induced tooth damage (dental fluorosis), bone damage (osteomalacia), neurotoxicity (reduced intelligence), and mutagenicity. The nutrients of primary importance appear to be calcium,
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Annapolis: Water Fluoridation Linked to Death of Dialysis Patient
EVENING CAPITAL (Annapolis, Maryland) November 29, 1979 Fluoride Linked to Death by Mary Ann Kryzankowicz Staff Writer Fluoride poisoning has been definitely linked to the death of a 65-year-old kidney dialysis patient who became ill during a blood cleaning process Nov 11. State Medical Examiner Dr. (illegible) Guard has ruled that Lawrence Blake, 65, of Arundel
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Skeletal Fluorosis & Individual Variability
One of the common fallacies in the research on skeletal fluorosis is the notion that there is a uniform level of fluoride that is safe for everyone in the population. These "safety thresholds" have been expressed in terms of (a) bone fluoride content, (b) daily dose, (c) water fluoride level, (d) urinary fluoride level, and (e) blood fluoride level. The central fallacy with each of these alleged safety thresholds, however, is that they ignore the wide range of individual susceptibility in how people respond to toxic substances, including fluoride.
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Fluoride Exposure Aggravates the Impact of Iodine Deficiency
A consistent body of animal and human research shows that fluoride exposure worsens the impact of an iodine deficiency. Iodine is the basic building block of the T3 and T4 hormones and thus an adequate iodine intake is essential for the proper functioning of the thyroid gland. When iodine intake is inadequate during infancy and
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Unheeded Warnings: Government Health Authorities Ignore Fluoride Risk for Kidney Patients
Despite the well known fact that individuals with kidney disease are at much higher risk of fluoride toxicity than the general population, there has yet to be any attempt in the United States, or any other country that practices mass-scale water fluoridation to determine the prevalence of fluoride-related effects (e.g.,
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