Abstract

The effects of feeding low levels of sodium fluoride from conception until old age were determined in a total of 456 albino rats. Four levels of sodium fluoride (0, 1, 5, and 10 PPM fluorine) were given to 4 groups of animals in their drinking water. In one study half of the rats were killed at 150 days of age and half at 520 days. In the second experiment all rats were killed at 150 days.

No evidence of injury to teeth was found in the animals killed at 150 days of age, but marked injury was noted in those given sodium fluoride supplementation until they were 520 days old. In old age missing teeth and periodontal disease were frequent in rats which had received sodium fluoride supplementation, especially at the higher levels.

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