Abstract
Fluoride (NaF, 50 mg/kg po) administration to rats caused an increased urinary excretion of inorganic phosphate, calcium, magnesium, potassium, and sodium associated with polyuria. The renal enzyme activities of Na+ and K+-stimulated adenosine triphosphatase [(Na+ + K+)-ATPase], Mg2+ and Ca2+-stimulated adenosine triphosphatase [(Mg2+ + Ca2+)-ATPase], acid phosphatase, and alkaline phosphatase were decreased by single oral doses of fluoride. A decrease in renal (Na+ + K+)-ATPase activity was associated with an increase in urine volume and a decrease in serum sodium concentration.
-
-
Induction of oxidative stress on reproductive and metabolic organs in sodium fluoride-treated male albino rats: protective effect of testosterone and vitamin E coadministration
The present study was undertaken to search out the effect of sodium fluoride, a water pollutant noted throughout the world, including India, on oxidative stress induction in reproductive tissues, sperm pellet, and metabolic tissues like the liver and kidney. The protective effects of testosterone or vitamin-E coadministration were also observed
-
Studies on effects of fluoride in 36 villages of Mehsana District, North Gujurat"
A survey was carried out in 36 fluoride endemic villages of Mehsana District of North Gujarat. Urine and blood samples of fluoride-afflicted human population and their drinking water were analysed for fluoride content and compared with samples from different parts of Ahmedabad city (control). The fluoride content in water samples
-
The structural and biochemical changes of kidney tissue on fluorosis in rabbit
In this study, the effects of sodium fluoride given subchronically at the doses of 1, 10 and 40 mg/L for 70 days were investigated. For this purpose, 21 male New Zealand rabbits were used. At the end of the 70th day, the level of blood urea nitrogen (BUN), creatine (CRE)
-
The in vitro and in vivo effects of fluoride on succinic dehydrogenase activity
-
Influence of increasing fluoride dose rates on selected liver and kidney enzymes profile in domestic chicken (Gallus domesticus)
Fluoride has been considered to cause hepatic and renal tissue damages in animals and humans. The present study investigated the effect of varying concentrations of fluoride on hepatic and renal enzyme profile in domestic chicken (n= 80). Chickens were distributed into 4 groups. Group A was kept unexposed while group
Related Studies :
-
-
-
Fluoride & Kidney Stones
It has long been suspected that fluoride may contribute to the formation of kidney stones. This suspicion has recently gained support from a study of an American man with skeletal fluorosis. According to the authors: "A new, important, medical problem (that seemed temporally related to cessation of fluoride exposure and subsequent negative calcium
-
Kidney: A potential target for fluoride toxicity
The kidneys are the organ responsible for clearing fluoride from the body. In the process of doing so, the kidneys are exposed to concentrations of fluoride that exceed, by a factor of 50, the concentration of fluoride in human blood. As such, the kidney have long been considered a potential
-
Fluoridation of drinking water and chronic kidney disease: Absence of evidence is not evidence of absence
A fairly substantial body of research indicates that patients with chronic renal insufficiency are at an increased risk of chronic fluoride toxicity. Patients with reduced glomerular filtration rates have a decreased ability to excrete fluoride in the urine. These patients may develop skeletal fluorosis even at 1 ppm fluoride in the drinking water.
-
Fluoride as a Cause of Kidney Disease in Humans
Because the kidney is exposed to higher concentrations of fluoride than all other soft tissues (with the exception of the pineal gland), there is concern that excess fluoride exposure may contribute to kidney disease - thus initiating a "vicious cycle" where the damaged kidneys increase the accumulation of fluoride, causing
-
Fluoride Gels & Kidney Function
Scientists have found that the application of "Fluoride Gels" at the dental office causes very high spikes in the blood fluoride level. The high spikes in blood fluoride levels are a result of three factors: the high concentration of fluoride in the gel (= 12.3 mg of fluoride in each
Related FAN Content :
-