Abstract
Thirty-six young rats were used to determine the effect of the fluoride on collagen synthesis in healing of fracture. Eighteen rats received 100 ppm fluoride per day, the other 18 were not given fluoride and were used as controls. Then the tibiae of the 36 rats were successively fractured and the animals killed. That is, the first 14 animals of either group were killed one a day, and then the remaining four animals were killed on days 21, 28, 35, and 45 as the tibiae were fractured. Collagen synthesis of the callus was examined histochemically and histologically. In the fluoride-treated group, collagen synthesis was found to be defective, while it was normal in the controls.
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Effect of slow-release sodium fluoride on cancellous bone histology and connectivity in osteoporosis
We have previously demonstrated that a treatment regimen of slow-release sodium fluoride (SRNaF) and continuous calcium citrate increases lumbar bone mass, improves cancellous bone material quality, and significantly reduces vertebral fracture rate in osteoporotic patients. In order to assess whether such treatment also improves trabecular structure, we quantitated cancellous bone
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Low-dose fluoride in postmenopausal women: a randomized controlled trial
CONTEXT: Trials of high-dose fluoride have reported increased bone formation and bone mineral density (BMD), but impaired bone mineralization and either adverse or neutral effects on fracture risk. Meta-analysis of a heterogeneous dataset of small trials suggests that daily doses of <20 mg fluoride might reduce fracture risk, but it is
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Fluoride domestic waters and systemic effects. I. Relation to bone-fracture experience, height, and weight of high school boys and young selectees of the armed forces of the United States
A study was made of the relation of fluoride (F) in drinking water to bone-fracture experience, height, and weight of high school boys and young adult males. Among high school boys the number of fractures per 100 boys varied from 21.3 to 32.4 The numbers of fractures to arms and legs
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Dual Energy X-Ray Absorptiometry (DXA) study of endemic skeletal fluorosis in a village of Nalgonda District, Andhra Pradesh, India
A comparative study of bone mineral density (BMD) and bone fracture was conducted in a fluorotic and a nonfluorotic area of the Nalgonda District, Andhra Pradesh, India. BMD measured by dual X- ray absorptiometry (DXA) of L2–L4 vertebrae, femoral neck, hip, and whole body was significantly higher by 112%, 43%,
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The effects of fluoridation on degenerative joint disease (DJD) and hip fractures
Fluoride strengthens bone, yet makes it more susceptible to fracture. If mechanical factors are important in DJD, an increased risk for DJD in communities where fluoride is consumed is also expected. Hip fractures and knee DJD joint replacements among those >65 years for 1991-1996 were compared between one community with
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Fluoride Content of Bone Impairs Bone Quality
Water Fluoridation Increases the Fluoride Content of Bone "Fluoride analyses of the cadaver material from Kuopio revealed that fluoridation of drinking water increases the fluoride concentration in bone. In some individual cases the amount of fluoride in trabecular bone may rise to relatively high levels, notably in patients with impaired renal
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Mechanisms by which fluoride may reduce bone strength
Based on a large body of animal and human research, it is now known that fluoride ingestion can reduce bone strength and increase the rate of fracture. There are several plausible mechanisms by which fluoride can reduce bone strength. As discussed below, these mechanisms include: Reduction in Cortical Bone Density De-bonding of
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Fluoride & Osteoarthritis
While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.
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The Relationship Between Fluoride, Bone Density, and Bone Strength
Although fluoride has generally been found to reduce the bone density of cortical bone, it is well documented that fluoride can increase the density of trabecular bone (aka cancellous bone). Trabecular bone is the primary bone of the spine, whereas cortical bone is the primary bone of the legs and arms. While increases in
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Fluoride in Water & Bone Fracture
Current epidemiological evidence indicates that the margin of safety between the level of fluoride in water that does, and does not, increase the risk of fracture is insufficiently large to protect all members of society from fluoride-induced damage to bone.
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