Abstract
Young rats were maintained, over a 2-week period, on laboratory chow and distilled water or water supplemented with 200 ppm fluoride. Metaphyseal and diaphyseal bone of the femurs and tibias of control and treated rats were analyzed. After fluoride treatment there was a decrease of lipid and citrate content and a decreased glucose utilization and lactate formation. The decrease in lipid content in bone from fluoride-treated rats was not mediated through diminished food intake or diminished weight gain of the experimental animals. It was accompanied by a significant decrease in, and alteration of the pattern of, lipid formation from acetate-J4C and citrate-1% . The decrease in citrate content was due to neither a decreased formation from exogenous acetate nor to an increased utilization of citrate. In contrast to bone, there was no fluoride effect on the total lipid or citrate content of liver. Femurs of fluoride-treated rats exhibited a decrease in mechanical strength as manifested by a decrease in ultimate stress to breaking as well as decrease in limit and modulus of elasticity.
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Effect of sodium fluoride on bone biomechanical and histomorphometric parameters and on insulin signaling and insulin sensitivity in ovariectomized rats
Osteoporosis is a systemic disease characterized by bone degradation and decreased bone mass that promotes increased bone fragility and eventual fracture risk. Studies have investigated the use of sodium fluoride (NaF) for the treatment of osteoporosis. However, fluoride can alter glucose homeostasis. The aim of this study was to evaluate
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The effect of fluoridated drinking water on the physical properties of the rat femur
Twenty-one-day old weanling albino rats were divided into paired control and experimental groups, both of which were given ad libitum supplies of rat cake diet and drinking water (fluoride ion content 0·2-0·3 p.p.m.). The drinking water of the experimental groups was supplemented by the addition of sodium flJioride to give
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Topical fluorides: effects on physiologic and biochemical processes
The ingestion of fluoride from dentifrices or mouthrinses can contribute substantially to the total daily intake of the ion, even in communities that provide optimally fluoridated drinking water. It is concluded that the frequent and unsupervised use of these products by children six years of age or younger, especially those living in
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The effect of dietary sodium fluoride on internal organs, breast muscle, and bones in captive American kestrels (Falco sparverius)
In 1982, 29 7-day-old American kestrel (Falco sparverius) chicks from captive stock were randomly assigned to one of three dietary regimens: (1) 10 birds were fed daily with cockerel mash (0 ppm of F-: control birds); (2) 10 birds were fed daily with cockerel mash containing 1,120 ppm of F-;
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The pathogenesis of endemic fluorosis: Research progress in the last 5 years.
Fluorine is one of the trace elements necessary for health. It has many physiological functions, and participates in normal metabolism. However, fluorine has paradoxical effects on the body. Many studies have shown that tissues and organs of humans and animals appear to suffer different degrees of damage after long-term direct
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Fluoride & Insulin
Insulin is a hormone produced by the pancreas that is responsible for maintaining appropriate levels of glucose in the blood. Insulin allows the body’s cells to take up glucose from the blood, and either use it as an energy source or store it as glycogen. Blood glucose levels in diabetics
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In Vitro Studies on Fluoride & Bone Strength
The "in vitro" research on fluoride and bone strength confirms what has repeatedly been found in animal and human studies: the more fluoride a bone has, the weaker the bone becomes. In an in vitro bone study, the researcher directly exposes a human or animal bone to a fluoride solution
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Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus
This section on Diabetes includes: • Fluoride & Impaired Glucose Tolerance • Fluoride & Insulin • Fluoride Sensitivity Among Diabetics • Fluoridated Water Causes Severe Dental Fluorosis in Children with Diabetes Insipidus • NRC (2006): Fluoride’s Effect on Glucose Metabolism Excessive exposure to fluoride causes a defect of the tooth enamel known as dental fluorosis. In
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Mechanisms by which fluoride may reduce bone strength
Based on a large body of animal and human research, it is now known that fluoride ingestion can reduce bone strength and increase the rate of fracture. There are several plausible mechanisms by which fluoride can reduce bone strength. As discussed below, these mechanisms include: Reduction in Cortical Bone Density De-bonding of
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Fluoride & Osteoarthritis
While the osteoarthritic effects that occurred from fluoride exposure were once considered to be limited to those with skeletal fluorosis, recent research shows that fluoride can cause osteoarthritis in the absence of traditionally defined fluorosis. Conventional methods used for detecting skeletal fluorosis, therefore, will fail to detect the full range of people suffering from fluoride-induced osteoarthritis.
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