Abstract
Gastroscopy to 35 patients with fluorosis, 32 with arsenic-fluorosis, and 25 control had been performed to study the influence of fluorosis on arsenic-fluorosis on the gastric mucosa. There was significant difference on gradient and activity of chronic gastritis among the three groups, but there was no significant difference in the fluorosis and arsenic-fluorosis [groups]. It appears that pathological changes of gastric mucosa of fluorosis and arsenic-fluorosis may be caused only by fluorosis.
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Gut microbiota perturbations and neurodevelopmental impacts in offspring rats concurrently exposure to inorganic arsenic and fluoride.
Many “hot spot” geographic areas across the world with drinking water co-contaminated with inorganic arsenic (iAs) and fluoride (F-), two of the most common natural contaminants in drinking water. Both iAs and F- are known neurotoxins and affect neurodevelopment of children. However, very few studies have investigated the neurodevelopmental effects
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Co-exposure to inorganic arsenic and fluoride prominently disrupts gut microbiota equilibrium and induces adverse cardiovascular effects in offspring rats.
Highlights Co-exposure to arsenic and fluoride leads to adverse cardiovascular effects. Co-exposure to arsenic and fluoride results in gut microbiota perturbations. Co-exposure causes more prominent effects than arsenic or fluoride alone. Strong correlations are identified between cardiovascular effects and significantly altered genera. Co-exposure to inorganic arsenic (iAs) and fluoride (F-)
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Effects of high fluoride and arsenic on brain biochemical indexes and learning-memory in rats
Nine-six Wistar rats were randomly divided into four groups of 24 rats in each group (female:male = 1:1). Over a period up to 90 days, with one untreated group as controls, the other three groups were administered, respectively, high fluoride (100 mg NaF/L), high arsenic (50 mg As2O3/L), or both
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Behavioral and general effects of subacute oral arsenic exposure in rats with and without fluoride
Consequences of oral arsenic and fluoride exposure on motor behavior and general toxicity were modeled in young adult male rats which received sodium (meta)arsenite (10 mg/kg-b.w.), sodium fluoride (5 mg/kg-b.w.), and their combination by gavage, once daily, 5 days a week for 6 weeks. After 6 weeks, 6 animals per group were dissected, while the
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Effect of arsenic and/or fluoride gestational exposure on renal autophagy in offspring mice.
Highlights The exposure of fluoride and arsenic in the mother rats induced the autophagy in the kidney of the offspring mice. Under the experimental conditions, the combination of As and F showed certain antagonistic effects. The expression of autophagy negative regulator p62 is increased, which may be due to autophagic
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