Fluoride Action Network


The aim of this study was to examine the influence of vitamin E on the liver morphology and carbohydrate enzyme activities of rats intoxicated with sodium fluoride (NaF). Eighteen adult male Wistar rats on a standard rat diet were divided into three equal groups for a five-week experiment: a control group on distilled water; an experimental group I dosed with 4 mg NaF/rat/24hr in the drinking water; and a group II with the same dose of NaF plus 3 mg vitamin E/rat/24hr. Pathomorphological changes in the liver were assessed by paraffin histopathology, and changes in protein content and carbohydrate enzyme activities of aldolase, malate dehydrogenase, lactate dehydrogenase, and sorbitol dehydrogenase were determined by standard methods. Under conditions of this study with rats, supplemental vitamin E partially but did not completely prevent the toxic effects of NaF on the liver histopathology and carbohydrate enzyme activities.